Pharmacogenetic testing in psychiatry: Perspective on clinical utility.

Journal: Asian journal of psychiatry

Volume: 86

Issue: 

Year of Publication: 2023

Affiliated Institutions:  Department of Mental Health, University of Port Harcourt, Rivers State, Nigeria. Electronic address: frances.adiukwu@uniport.edu.ng. Department of Neuropsychiatry, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. Electronic address: adesaayo@gmail.com. Department of Psychiatry, University of Calabar, Calabar, Nigeria. Electronic address: mannyessien@gmail.com. Department of Clinical Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara , Turkey. Electronic address: nadir.yalcin@hacettepe.edu.tr. Department of Psychiatry, Clinical Neurosciences and Addiction Medicine, All India Institute of Medical Sciences, Guwahati, Assam , India. Electronic address: ramdas_ransing@yahoo.co.in. St Johns Medical College Hospital, Bangaluru , India. Electronic address: sachin.n@stjohns.in. Department of Psychiatry, Faculty of Medicine, Prince Songkhla University, Songkhla , Thailand. Electronic address: jchonnak@gmail.com. Child and Adolescent Psychiatry Unit, Department of Behavioural Sciences, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, Nigeria. Department of Psychiatry, Al Amal Psychiatric Hospital, Dubai, United Arab Emirates. Electronic address: faisal.nawaz@ehs.gov.ae. CHiMES Collaborative, Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford OX JX, UK. Electronic address: nagina.khan@psych.ox.ac.uk.

Abstract summary 

Pharmacogenetic studies the influence of inherited characteristics on medication. While different from pharmacogenomics, which is a study of the entire genome in relation to medication effect, their distinction remains inconsistent, and the two terms are used interchangeably. Although the potential of pharmacogenomics in psychiatry is apparent and its clinical utility is suboptimal, the uptake of recommendations and guidelines is minimal and research into PGx is not diverse. This article offers an overview of pharmacogenetics (PGx) in psychiatry, explores the difficulties, and provides recommendations on improving its applicability and clinical utility.

Authors & Co-authors:  Adiukwu Frances F Adesokun Olufisayo O Essien Emmanuel E Yalcin Nadir N Ransing Ramdas R Nagendrappa Sachin S Jatchavala Chonnakarn C Olakunke Ayotunde Bolatito AB Nawaz Faisal A FA Khan Nagina N

Study Outcome 

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Statistics
Citations : 
Authors :  10
Identifiers
Doi : 10.1016/j.ajp.2023.103674
SSN : 1876-2026
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Pharmacogenomics;Precision medicine;Psychiatry PGx
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
Netherlands