Towards a youth mental health paradigm: a perspective and roadmap.

Journal: Molecular psychiatry

Volume: 28

Issue: 8

Year of Publication: 2023

Affiliated Institutions:  Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK. peter.uhlhaas@charite.de. Department of Psychiatry, The University of Melbourne, Carlton, VIC, Australia. Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Department of Psychiatry, McGill University, Montreal, QC, Canada. Division of Digital Psychiatry and Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Department of Psychology, University of Oregon, Eugene, OR, USA. Office of the Director, National Institute of Mental Health, Bethesda, MD, USA. Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Orygen: National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia. Department of Psychiatry, University of Hong Kong, Hong Kong, China. Department of Child and Adolescent Psychiatry, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada. Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia. Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, RWTH, Aachen, Germany. Department of Psychiatry, Weill Cornell Cornell Medicall College, New York, NY, USA. Departments of Pediatrics and Psychiatry, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. CORE-Copenhagen Research Centre for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Faculty of Health and Medical Sciences, Department of Clinical Medicine, Hellerup, Denmark. McLean Hospital/Harvard Medical School, Belmont, MA, USA. Centre for Adolescent Health, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC, Australia. Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte Justine, University of Montreal, Montreal, QC, Canada. Department of Public Mental Health, Central Institute of Mental Health, Medical Faculty Mannheim, Mannheim, Germany. The John Hopkins Schizophrenia Center, Johns Hopkins University, Baltimore, MD, USA. Division of Service and Intervention Research, National Institute of Mental Health, Bethesda, MD, USA. Centre for Population Neuroscience and Stratified Medicine, ISTBI, Fudan University, Shanghai, China. Department of Psychiatry, Yale University, New Haven, CT, USA. Departments of Epidemiology and Psychiatry, Columbia University, New York, NY, USA. Department of Psychosis, Institute of Mental Health, Buangkok, Singapore. Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA. Department of Social and Behavioral Sciences, New York University, New York, NY, USA. School of Medicine, Faculty of Health, Deakin University, Melbourne, VIC, Australia.

Abstract summary 

Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health. This perspective addresses interactions between risk and protective factors and brain development as key pillars accounting for the emergence of psychopathology in youth. Moreover, we propose that novel approaches towards early diagnosis and interventions are required that reflect the evolution of emerging psychopathology, the importance of novel service models, and knowledge exchange between science and practitioners. Taken together, we propose a transformative early intervention paradigm for research and clinical care that could significantly enhance mental health in young people and initiate a shift towards the prevention of severe mental disorders.

Authors & Co-authors:  Uhlhaas Peter J PJ Davey Christopher G CG Mehta Urvakhsh Meherwan UM Shah Jai J Torous John J Allen Nicholas B NB Avenevoli Shelli S Bella-Awusah Tolulope T Chanen Andrew A Chen Eric Y H EYH Correll Christoph U CU Do Kim Q KQ Fisher Helen L HL Frangou Sophia S Hickie Ian B IB Keshavan Matcheri S MS Konrad Kerstin K Lee Francis S FS Liu Cindy H CH Luna Beatriz B McGorry Patrick D PD Meyer-Lindenberg Andreas A Nordentoft Merete M Öngür Dost D Patton George C GC Paus Tomáš T Reininghaus Ulrich U Sawa Akira A Schoenbaum Michael M Schumann Gunter G Srihari Vinod H VH Susser Ezra E Verma Swapna K SK Woo T Wilson TW Yang Lawrence H LH Yung Alison R AR Wood Stephen J SJ

Study Outcome 

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Statistics
Citations :  Insel TR, Fenton WS. Psychiatric epidemiology: it’s not just about counting anymore. Arch Gen Psychiatry. 2005;62:590–2. doi: 10.1001/archpsyc.62.6.590.
Authors :  37
Identifiers
Doi : 10.1038/s41380-023-02202-z
SSN : 1476-5578
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Publication Country
England