Anxiety symptoms and mild cognitive impairment among community-dwelling older adults from low- and middle-income countries.
Journal: Journal of affective disorders
Volume: 291
Issue:
Year of Publication: 2021
Affiliated Institutions:
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, CB PT, United Kingdom. Electronic address: Lee.Smith@aru.ac.uk.
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Dr. Antoni Pujadas, , Sant Boi de Llobregat, Barcelona , Spain; Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux , France.
Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, United Kingdom.
Faculty of Science and Engineering, Anglia Ruskin University, Cambridge, CB PT, United Kingdom.
Anglia Ruskin University, Cambridge, CB PT, United Kingdom.
Department of Medicine, Geriatrics Section, University of Palermo, Palermo, Italy.
Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Canada; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Department of Social and Behavioural Science, Medical University of Vienna, Kinderspitalgasse /, Wien, Austria.
Institute of Mental Health Sciences, School of Health Sciences, Ulster University, Newtownabbey, United Kingdom.
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Dr. Antoni Pujadas, , Sant Boi de Llobregat, Barcelona , Spain; ICREA, Pg. Lluis Companys , , Barcelona, Spain.
Abstract summary
Anxiety may be a risk factor for mild cognitive impairment (MCI) but there is a scarcity of data on this association especially from low- and middle-income countries (LMICs). Thus, we investigated the association between anxiety and MCI among older adults residing in six LMICs (China, Ghana, India, Mexico, Russia, South Africa), and the mediational effect of sleep problems in this association.Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. Multivariable logistic regression analysis, meta-analysis, and mediation analysis were conducted to assess associations.The final sample included 32,715 individuals aged ≥50 years with preservation in functional abilities [mean (standard deviation) age 62.1 (15.6) years; 48.3% males]. Country-wise analysis showed a positive association between anxiety and MCI in all countries (OR 1.35-14.33). The pooled estimate based on meta-analysis with random effects was OR=2.27 (95%CI=1.35-3.83). Sleep problems explained 41.1% of this association.Older adults with anxiety had higher odds for MCI in LMICs. Future studies should examine whether preventing anxiety or addressing anxiety among individuals with MCI can lead to lower risk for dementia onset in LMICs, while the role of sleep problems in this association should be investigated in detail.
Authors & Co-authors:
Smith Lee L
Jacob Louis L
López-Sánchez Guillermo F GF
Butler Laurie L
Barnett Yvonne Y
Veronese Nicola N
Soysal Pinar P
Yang Lin L
Grabovac Igor I
Tully Mark A MA
Shin Jae Il JI
Koyanagi Ai A
Study Outcome
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