Toxic effect of khat () on memory: Systematic review and meta-analysis.

Journal: Journal of neurosciences in rural practice

Volume: 8

Issue: 1

Year of Publication: 

Affiliated Institutions:  Department of Anatomy and Histology, Institute of Bio-Medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Department of Biochemistry and Molecular Biology, Institute of Bio-Medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Department of Pediatrics and Gynecology, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. Department of Physiology, Institute of Bio-Medical Sciences, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Abstract summary 

People use khat () for its pleasant stimulant effect of physical activity, consciousness, motor, and mental functions. Although there are reports assessing the effect of khat on memory, there was no study based on formal systematic review and meta-analysis.We have therefore conducted this meta-analysis to determine the level of evidence for the effect of khat ( Forsk) on memory discrepancy.MEDLINE, Cochrane Library, PubMed, Academic Search Complete, SPORTDiscus, ScienceDirect, Scopus, Web of Science, and Google Scholar were searched to retrieve the papers for this review. Keywords utilized across database search were khat, cat, chat, long-term memory, short-term memory, memory deficit, randomized control trial, and cross-sectional survey. The search was limited to studies in humans and rodents; published in English language.Finding of various studies included in our meta-analysis showed that the effect of acute, and subchronic exposure to khat showed that short-term memory appears to be affected depending on the duration of exposure. However, does not have any effect on long-term memory.Although a number of studies regarding the current topic are limited, the evidenced showed that khat () induced memory discrepancy.

Authors & Co-authors:  Berihu Birhane Alem BA Asfeha Gebrekidan Gebregzabher GG Welderufael Abadi Leul AL Debeb Yared Godefa YG Zelelow Yibrah Berhe YB Beyene Hafte Assefa HA

Study Outcome 

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Citations :  Gebissa E. Khat in the Horn of Africa: historical perspectives and current trends. J Ethnopharmacol. 2010;132:607–14.
Authors :  6
Identifiers
Doi : 10.4103/0976-3147.193524
SSN : 0976-3147
Study Population
Male,Female
Mesh Terms
Other Terms
Catha edulis;Qat;khat;long-term memory;reference memory;short-term memory;working memory
Study Design
Randomized Control Trial,,Case Control Trial,Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
United States