Association between hypertensive disorders of pregnancy and the development of offspring mental and behavioural problems: A systematic review and meta-analysis.

Journal: Psychiatry research

Volume: 260

Issue: 

Year of Publication: 2018

Affiliated Institutions:  The University of Queensland, Institute for Social Science Research, Indooroopilly, Qld , Australia; The University of Queensland, School of Public Health, Herston, Qld , Australia; Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Ethiopia. Electronic address: b.dachew@uq.edu.au. The University of Queensland, Institute for Social Science Research, Indooroopilly, Qld , Australia; The University of Queensland, School of Public Health, Herston, Qld , Australia. Electronic address: mamun@sph.uq.edu.au. The University of Queensland, Institute for Social Science Research, Indooroopilly, Qld , Australia; The University of Queensland, School of Public Health, Herston, Qld , Australia. Electronic address: j.maravilla@uq.edu.au. The University of Queensland, Institute for Social Science Research, Indooroopilly, Qld , Australia; The University of Queensland, School of Public Health, Herston, Qld , Australia. Electronic address: r.alati@sph.uq.edu.au.

Abstract summary 

Hypertensive disorders of pregnancy are a major cause of maternal and offspring morbidity and mortality worldwide. However, its effect on offspring mental and behavioural disorders is unclear. The aim of this study is to provide the best scientific evidence on the association between hypertensive disorders of pregnancy and offspring mental and behavioural problems. We systematically searched Scopus, PubMed, Cochrane, EMBASE, CINAH and PsycINFO databases. A total of 23 studies (11 included in meta-analysis) were identified. Of the 23 studies included in this review, 15 studies found that hypertensive disorders of pregnancy had a negative impact for at least one mental or behavioural disorder. The pooled effect of 11 studies included in the meta-analysis showed that preeclampsia was associated with increased risk of offspring schizophrenia. However, we found inconclusive finding on the effect of hypertensive disorders of pregnancy and other mental and behavioural disorders. Further high quality, large sample, birth cohort studies are needed to further progress this area of research.

Authors & Co-authors:  Dachew Berihun Assefa BA Mamun Abdullah A Maravilla Joemer Calderon JC Alati Rosa R

Study Outcome 

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Statistics
Citations : 
Authors :  4
Identifiers
Doi : 10.1016/j.psychres.2017.12.027
SSN : 1872-7123
Study Population
Male,Female
Mesh Terms
Case-Control Studies
Other Terms
Behavioural disorders;Hypertensive disorders of pregnancy;Mental disorders;Offspring
Study Design
Cohort Study,Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Publication Country
Ireland