The Loss of α- and β-Tubulin Proteins Are a Pathological Hallmark of Chronic Alcohol Consumption and Natural Brain Ageing.
Journal: Brain sciences
Volume: 8
Issue: 9
Year of Publication:
Affiliated Institutions:
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. wajana.lako@aau.edu.et.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. A.Raulin@sussex.ac.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. lucky.nwidu@uniport.edu.ng.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. msxamk@nottingham.ac.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. stxdw@exmail.nottingham.ac.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. amaia.m.erdozain@gmail.com.
Section of Forensic Pathology, Basque Institute of Legal Medicine, Bilbao , Spain. morentin.b@justizia.eus.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. danielaschwendener@gmail.com.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. george.allen@doctors.org.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. jack.enticott@btinternet.com.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. henry.k.gerdes@gmail.com.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. laurajohnsonLJ@hotmail.co.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. stxjwg@exmail.nottingham.ac.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. sbafd@exmail.nottingham.ac.uk.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. mdzrr@exmail.nottingham.ac.uk.
Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE , USA. nosna@unmc.edu.
Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE , USA. kkharbanda@unmc.edu.
Department of Pharmacology, University of the Basque Country, Leioa-Erandio , Spain. lf.callado@ehu.eus.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE DT, UK. wayne.carter@nottingham.ac.uk.
Abstract summary
Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human tissue from Brodmann's area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals were divided into equal groups of 11 control, 11 alcoholic, 11 non-alcoholic suicides, and 11 suicide alcoholics matched for age, sex, and delay. Tissue from alcoholic cohorts displayed significantly reduced expression of α- and β-tubulins, and increased levels of acetylated α-tubulin. Protein levels of histone deacetylase-6 (HDAC6), and the microtubule-associated proteins MAP-2 and MAP-tau were reduced in alcoholic cohorts, although for MAPs this was not significant. Tubulin gene expressions increased in alcoholic cohorts but not significantly. Brains from rats administered alcohol for 4 weeks also displayed significantly reduced tubulin protein levels and increased α-tubulin acetylation. PFC tissue from control subjects had reduced tubulin protein expression that was most notable from the sixth to the eighth decade of life. Collectively, loss of neuronal tubulin proteins are a hallmark of both chronic alcohol consumption and natural brain ageing. The reduction of cytosolic tubulin proteins could contribute to the brain volumetric losses reported for alcoholic patients and the elderly.
Authors & Co-authors:
Labisso Wajana L WL
Raulin Ana-Caroline AC
Nwidu Lucky L LL
Kocon Artur A
Wayne Declan D
Erdozain Amaia M AM
Morentin Benito B
Schwendener Daniela D
Allen George G
Enticott Jack J
Gerdes Henry K HK
Johnson Laura L
Grzeskowiak John J
Drizou Fryni F
Tarbox Rebecca R
Osna Natalia A NA
Kharbanda Kusum K KK
Callado Luis F LF
Carter Wayne G WG
Study Outcome
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