Genotype-phenotype feasibility studies on khat abuse, traumatic experiences and psychosis in Ethiopia.

Journal: Psychiatric genetics

Volume: 30

Issue: 1

Year of Publication: 2020

Affiliated Institutions:  Institute of Psychiatric Phenomics and Genomics. Department of Medical Laboratory Sciences and Pathology, Jimma University, Jimma, Ethiopia. Department of Epidemiology, Jimma University, Jimma, Ethiopia. Institute of Human Genetics, University of Bonn, Germany. Department of Psychology, University of Konstanz, Konstanz, Germany. Department of Forensic Toxicology, Goethe University, Frankfurt am Main, Germany. Department of Psychiatry, Jimma University. School of Pharmacy, Faculty of Health Sciences, Jimma University Institute of Health, Jimma, Ethiopia. Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. Department of Psychiatry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. Mailman School of Public Health, Columbia University. Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany and.

Abstract summary 

Studying the relationship between mental illnesses and their environmental and genetic risk factors in low-income countries holds excellent promises. These studies will improve our understanding of how risk factors identified predominantly in high-income countries also apply to other settings and will identify new, sometimes population-specific risk factors. Here we report the successful completion of two intertwined pilot studies on khat abuse, trauma, and psychosis at the Gilgel Gibe Field Research Center in Ethiopia. We found that the Gilgel Gibe Field Research Center offers a unique opportunity to collect well-characterized samples for mental health research and to perform genetic studies that, at this scale, have not been undertaken in Ethiopia yet. We also supported service development, education, and research for strengthening the professional profile of psychiatry at the site.

Authors & Co-authors:  Adorjan Kristina K Mekonnen Zeleke Z Tessema Fasil F Ayana Mio M Degenhardt Franziska F Hoffmann Per P Fricker Nadine N Widmann Marina M Riedke Heike H Toennes Stefan W SW Soboka Matiwos M Suleman Sultan S Andlauer Till F M TFM Tesfaye Markos M Rietschel Marcella M Susser Ezra E Odenwald Michael M Schulze Thomas G TG Mattheisen Manuel M

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Adorjan K, Odenwald M, Widmann M, Tesfaye M, Tessema F, Toennes S, et al. Khat use and occurrence of psychotic symptoms in the general male population in Southwestern Ethiopia: evidence for sensitization by traumatic experiences. World Psychiatry. 2017; 16:323
Authors :  19
Identifiers
Doi : 10.1097/YPG.0000000000000242
SSN : 1473-5873
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Study Design
Cross Sectional Study
Study Approach
Country of Study
Ethiopia
Publication Country
England