Abstract summary 

Bacterial meningitis is a medical emergency that requires immediate medical attention. It causes an estimated 288,649 deaths worldwide per year, of which 94,883 death occur among children under 5 years old. Up to 24% of survivors suffer from long-term sequelae such as epilepsy, mental disability, or sensorineural deafness, especially when the disease is contracted during early childhood.This study aimed to assess bacterial isolates of cerebrospinal fluid (CSF) samples and their antimicrobial resistance patterns among children under 5 years old in Dilla University Referral Hospital.Hospital-based cross-sectional study design was used to collect clinical data and CSF sample from children under 5 years old who were suspected for meningitis. Sediment of CSF samples was inoculated to blood agar plate, chocolate agar plate, and MacConkey agar for bacterial isolation and identification. Chemical analysis and cytological analysis were also conducted based on standard operating procedures.From a total of 287 CSF samples cultured, causative bacteria were detected in 38 (13.2%). From culture positive cases, the most frequent isolate was (13 (34.2%)) followed by (7 (18.4%)), (6 (16%)) and (6 (16%)). type b was isolated in 4 (10.5%) children with meningitis. Another cause of meningitis was which accounted for 10.5%. was detected in 4 (1.9%) cases of meningitis. Of all bacterial isolates, about 42.1% (16/38) were multi-drug resistant. About 38.5% of had multi-drug resistance, while about 33.3% of , 50% , 57.1% and 40% of showed multi-drug resistance.A high prevalence of bacterial meningitis and high rate of drug resistance were observed. was the leading cause of bacterial meningitis among children under 5 years old.

Authors & Co-authors:  Awulachew Ephrem E Diriba Kuma K Awoke Netsanet N

Study Outcome 

Source Link: Visit source