Abstract summary 

To investigate the association between placental genome-wide methylation at birth and antenatal depression and stress during pregnancy. We examined the association between placental genome-wide DNA methylation (n = 301) and maternal depression and stress assessed at six gestation periods during pregnancy. Correlation between DNA methylation at the significantly associated CpGs and expression of nearby genes in the placenta was tested. Depression and stress were associated with methylation of 16 CpGs and two CpGs, respectively, at a 5% false discovery rate. Methylation levels at two of the CpGs associated with depression were significantly associated with expression of and , genes implicated in neurodevelopment and neuropsychiatric diseases. Placental epigenetic changes linked to antenatal depression suggest potential fetal brain programming. Clinical trial registration number: NCT00912132 (ClinicalTrials.gov).

Authors & Co-authors:  Tesfaye Markos M Chatterjee Suvo S Zeng Xuehuo X Joseph Paule P Tekola-Ayele Fasil F

Study Outcome 

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