Abstract summary 

Even though several factors affect reference intervals (RIs), company-derived values are currently in use in many laboratories worldwide. However, few or no data are available regarding serum proteins RIs, especially in resource-limited countries such as Ethiopia.To establish RIs for serum protein electrophoresis of apparently healthy adults in Addis Ababa, Ethiopia.A cross-sectional study was conducted on a total of 297 apparently healthy adults from April to October 2019 in four selected sub-cities (Akaki, Kirkos, Arada, and Yeka) of Addis Ababa, Ethiopia. Laboratory analysis of collected samples was performed using the Capillarys 2 Flex Piercing analyzer, while statistical analysis was conducted using SPSS version 23 and Med-Calc software. The Mann-Whitney test was used to check partitions. A non-parametric method of reference range establishment was performed as per CLSI guideline EP28A3C.The established RIs were: albumin 53.83-64.59%, 52.24-63.55%; alpha-1 globulin 3.04-5.40%, 3.44-5.60%; alpha-2 globulin 8.0-12.67%, 8.44-12.87%; and beta-1 globulin 5.01-7.38%, 5.14-7.86%. Moreover, the albumin to globulin ratios were 1.16-1.8 and 1.09-1.74 for males and females, respectively. The combined RIs for beta-2 globulin and gamma globulin were 2.54-4.90% and 12.40-21.66%, respectively.The established reference interval for serum protein fractions revealed gender-specific differences, except for beta-2 globulin and gamma globulin.

Authors & Co-authors:  Bikila Demiraw D Lejisa Tadesse T Tolcha Yosef Y Bashea Chala C Meles Mehari M Getahun Tigist T Ashebir Genet G Habtu Wossene W Challa Feyissa F Mohammed Ousman O Kassaw Melkitu M Kebede Adisu A G/Egzeabher Letebrhan L Befekadu Endalkachew E Wolde Mistire M Tsegaye Aster A

Study Outcome 

Source Link: Visit source