Assessments of functional outcomes and its determinants among bipolar disorder patients in Northwest Ethiopia comprehensive specialized hospitals: a multicenter hospital-based study.

Journal: Annals of general psychiatry

Volume: 22

Issue: 1

Year of Publication: 

Affiliated Institutions:  Department of Clinical Pharmacy, School of Pharmacy, University of Gondar-College of Medicine and Health Science, Gondar, Ethiopia. School of Public Health, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, Addis Ababa, Ethiopia. Department of Pharmacy, College of Medicine and Health Science, Woldia University, P.O. Box: , Woldia, Ethiopia. abebetare@gmail.com. Department of Pharmacy, College of Medicine and Health Science, Debre Markos University Debre Markos, Debre Markos, Ethiopia.

Abstract summary 

Bipolar disorder is a severe and chronic mental illness that could continue for a lifetime. Although it is a leading cause of disability and impairments for significant numbers of patients, the levels of functional outcomes have not been studied in Ethiopia. Therefore, this study aimed to assess the functional outcome levels and associated factors among bipolar disorder patients in Northwest Ethiopia.Hospital-based cross-sectional study was employed among bipolar disorder patients attending psychiatric clinics, in Northwest Ethiopia, from April to June 2021. Systematic random sampling was used to get respondents. Descriptive and inferential statistics were done. Data were entered into EpiData version 4.6.02 and exported to SPSS Version 22 for analysis. Bivariable and multivariable binary logistic regression analysis was used to identify the factors associated with functional outcome levels, and p value < 0.05 was considered significant with 95% CI.Of the total 423 study participants approached, only 411 completed the questionnaire, with a response rate of 97.2%. The median (IQR) level of functional outcome was 6 (0-22) and 40% of the study subjects were impaired. Leisure time was the most normal functioning domain (92.2%), whereas cognitive (43.5%) and occupational (41.6%) domains were the most impaired domains. Unemployment (AOR (95%CI) = 3.9 (1.46-10.49), obesity (AOR (95% CI) = 6.5 (1.22-34.58), depressed and manic mood phases (AOR (95%CI) = 5.2 (2.84-9.35) and (AOR (95%CI) = 7.8 (3.31-18.34) respectively, medication non-adherence (AOR (95% CI) = 3.2 (1.71-6.05), and relapsed once or ≥ twice (AOR (95%CI) = 2.2 (1.25-3.98) and (AOR (95%CI) = 8.3 (2.73-25.30), respectively, were some of the important predictor variables that were significantly associated to the functional impairments levels.The median of functional outcomes levels was found in an acceptable range; however, significant numbers of bipolar patients were functionally impaired. Moreover, patients still need unrestricted interventions in the cognitive and occupational functional domains. Socio-demographic, clinical, medication, and psychosocial variables were significantly associated with functional outcomes. Bipolar patients need to be followed and managed to improve their functional outcome and all stakeholders should be involved to achieve the recommended levels.

Authors & Co-authors:  Mengistu Melak Erara ME Berassa Simegnew Handebo SH Kassaw Abebe Tarekegn AT Dagnew Ephrem Mebratu EM Mekonen Gizework Alemnew GA Birarra Mequanent Kassa MK

Study Outcome 

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Statistics
Citations :  Rosa AR, et al. Functional impairment and disability across mood states in bipolar disorder. Value Health. 2010;13(8):984–988.
Authors :  6
Identifiers
Doi : 14
SSN : 1744-859X
Study Population
Male,Female
Mesh Terms
Other Terms
Bipolar disorder;Functional outcomes;Impairment;Northwest Ethiopia
Study Design
Descriptive Study,Cross Sectional Study
Study Approach
Systemic Review
Country of Study
Ethiopia
Publication Country
England