Burden of post-traumatic stress disorder in postgenocide Rwandan population following exposure to 1994 genocide against the Tutsi: A meta-analysis.

Journal: Journal of affective disorders

Volume: 275

Issue: 

Year of Publication: 2021

Affiliated Institutions:  Centre for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda; Medical Research Center, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda; Genomics Program, College of Public Health, University of South Florida, Florida, USA. Department of Clinical Psychology, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda; Directorate of Research and Innovation, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London, UK; Uganda Medical Informatics Centre-MRC/UVRI, Entebbe, Uganda; Genomics Program, College of Public Health, University of South Florida, Florida, USA. Department of Clinical Psychology, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda. Centre for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. Division of Mental Health, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda. Department of Pharmacology, School of Medicine, University of California Irvine, California, USA. Genomics Program, College of Public Health, University of South Florida, Florida, USA. Centre for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda. Electronic address: lmutesa@gmail.com.

Abstract summary 

The 1994 genocide against Tutsi resulted in a massive death toll that reached one million people. Despite the tremendous efforts made to mitigate the adverse effects of the genocide, a substantial burden of mental health disorders still exists including the notably high prevalence of post-traumatic stress disorder (PTSD) among genocide survivors. However, a synthesized model of PTSD vulnerability in this population is currently lacking.A meta-analysis of 19 original research studies that reported PTSD prevalence (n = 12,610). Medline-PubMed and Science.gov were key search engines. Random-Effects Model (k = 19; tau^2 estimator: DL) was applied. Data extraction, synthesis, and meta-analysis were carried out using R.The total of 2957 out of 11,746 individuals suffered from PTSD. The summary proportion is 25% (95% CI=0.16,0.36). The tau^2 is 0.06 (95% CI=0.03,0.14) in the absence of subgroups, and the Q-statistic is 2827.65 (p<0.0001), all of which suggests high heterogeneity in the effect sizes. Year of data collection and Year of publication were significant moderators. PTSD pooled prevalence in the genocide survivor category was estimated at 37% (95% CI=0.21,0.56).The PTSD prevalence among genocide survivors is considerably higher compared to the general Rwandan population. The burden of PTSD in the general Rwandan population declined significantly over time, likely due to treatment of symptoms through strong national mental health programs, peace building and resolution of symptoms over time. To the best of our knowledge little evidence has reported the burden of PTSD prevalence in African post conflict zones particularly in Rwanda.Limitations of our review include the use of retrospective studies and studies with very small sample sizes, as well as language criterion.

Authors & Co-authors:  Musanabaganwa Clarisse C Jansen Stefan S Fatumo Segun S Rutembesa Eugene E Mutabaruka Jean J Gishoma Darius D Uwineza Annette A Kayiteshonga Yvonne Y Alachkar Amal A Wildman Derek D Uddin Monica M Mutesa Leon L

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Cobain RN. When Nothing Matters Anymore: A Survival Guide for Depressed Teens: Easyread Super Large 24pt Edition 2009;(February):1–5.
Authors :  12
Identifiers
Doi : 10.1016/j.jad.2020.06.017
SSN : 1573-2517
Study Population
Male,Female
Mesh Terms
Genocide
Other Terms
Biological mechanisms;Genocide;PTSD;Prevalence;Rwanda
Study Design
Study Approach
Country of Study
Rwanda
Publication Country
Netherlands