Optimal Cutoff Scores for Alzheimer's Disease Using the Chinese Version of Mini-Mental State Examination Among Chinese Population Living in Rural Areas.

Journal: American journal of Alzheimer's disease and other dementias

Volume: 31

Issue: 8

Year of Publication: 2017

Affiliated Institutions:  Department of Cancer Epidemiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Department of Family Medicine, Rush University Medical College, Chicago, IL, USA. Department of Cancer Epidemiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China fanjh@cicams.ac.cn mali_lele@sina.com. Department of Epidemiology, Dalian Medical University, Dalian, People's Republic of China. Department of Neurology, The Second Affiliated Hospital of Dalian, Dalian, People's Republic of China. Food and Drug Administration, Silver Spring, MD, USA. Department of Neurology, University of California Davis, Davis, CA, USA.

Abstract summary 

To explore the optimal cutoff score for initial detection of Alzheimer's Disease (AD) through the Chinese version of Mini-Mental State Examination (CMMSE) in rural areas in China, we conducted a cross-sectional study within the Linxian General Population Nutritional Follow-up study. 16,488 eligible cohort members participated in the survey and 881 completed the CMMSE. Among 881 participants, the median age (Interquartile range) was 69.00 (10.00), 634 (71.92%) were female, 657 (74.57%) were illiterate, 35 (3.97%) had 6 years of education or higher, and 295 (33.48%) were diagnosed with AD. By reducing the CMMSE criteria for illiterate to 16 points, primary school to 19 points, and middle school or higher to 23 points, the efficiency of Chinese version of Mini-Mental State Examination can be significantly improved for initial detection of AD in rural areas in China, especially in those nutrition deficient areas.

Authors & Co-authors:  Yang Zhao Z Holt Hunter K HK Fan Jin-Hu JH Ma Li L Liu Ying Y Chen Wen W Como Peter P Zhang Lin L Qiao You-Lin YL

Study Outcome 

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Statistics
Citations :  Prince M, Wimo A, Guerchet M, Ali G, Wu YT, Prina M. World Alzheimer Report 2015—The global impact of dementia: an analysis of prevalence, incidence, cost and trends. London: Alzheimer’s Disease International; 2015.
Authors :  9
Identifiers
Doi : 
SSN : 1938-2731
Study Population
Male,Female
Mesh Terms
Aged
Other Terms
Alzheimer’s disease;Chinese population;Chinese version Mini-Mental State Examination;ROC analysis;cutoff scores;rural areas
Study Design
Study Approach
Country of Study
Publication Country
United States