Evaluation and treatment approaches for neurological post-acute sequelae of COVID-19: A consensus statement and scoping review from the global COVID-19 neuro research coalition.
Journal: Journal of the neurological sciences
Volume: 454
Issue:
Year of Publication: 2023
Affiliated Institutions:
Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: jennifer.frontera@nyulangone.org.
Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia.
Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Department of Anesthesiology, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY, USA.
Department of Neurology, Istanbul University, Istanbul Faculty of Medicine, and EMAR Medical Center, Istanbul, Turkey.
The Encephalitis Society, Malton, UK; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Department of Neurology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Department of Neurology, Neuro-Intensive Care Unit, Medical University of Innsbruck, Innsbruck, Austria; Department of Neurology, Johannes Kepler University, Linz, Austria.
Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany.
Departmentof Neurology, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India.
Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, UK; The Walton Centre NHS Foundation Trust, Liverpool, UK.
Clinical Neurology, Santa Maria della Misericordia University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy.
Department of Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey.
Department of Neurology, New York University Grossman School of Medicine, New York, NY, USA.
Chief Executive Office, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento Universitario Di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Internal Medicine, University Teaching Hospital, Lusaka, Zambia.
The Walton Centre NHS Foundation Trust, Liverpool, UK.
Department of Neurology, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY, USA.
Clinical Neurology, Santa Maria della Misericordia University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy; Department of Medicine, University of Udine Medical School, Udine, Italy.
Department of Neurology, Universitätsklinikum Erlangen, Erlangen, Germany; Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia.
Department of Neurology, Center for Global Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway; Blavatnik Institute of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Abstract summary
Post-acute neurological sequelae of COVID-19 affect millions of people worldwide, yet little data is available to guide treatment strategies for the most common symptoms. We conducted a scoping review of PubMed/Medline from 1/1/2020-4/1/2023 to identify studies addressing diagnosis and treatment of the most common post-acute neurological sequelae of COVID-19 including: cognitive impairment, sleep disorders, headache, dizziness/lightheadedness, fatigue, weakness, numbness/pain, anxiety, depression and post-traumatic stress disorder. Utilizing the available literature and international disease-specific society guidelines, we constructed symptom-based differential diagnoses, evaluation and management paradigms. This pragmatic, evidence-based consensus document may serve as a guide for a holistic approach to post-COVID neurological care and will complement future clinical trials by outlining best practices in the evaluation and treatment of post-acute neurological signs/symptoms.
Authors & Co-authors:
Frontera Jennifer A JA
Guekht Alla A
Allegri Ricardo F RF
Ashraf Mariam M
Baykan Betül B
Crivelli Lucía L
Easton Ava A
Garcia-Azorin David D
Helbok Raimund R
Joshi Jatin J
Koehn Julia J
Koralnik Igor I
Netravathi M M
Michael Benedict B
Nilo Annacarmen A
Özge Aynur A
Padda Karanbir K
Pellitteri Gaia G
Prasad Kameshwar K
Romozzi Marina M
Saylor Deanna D
Seed Adam A
Thakur Kiran K
Uluduz Derya D
Vogrig Alberto A
Welte Tamara M TM
Westenberg Erica E
Zhuravlev Dmitry D
Zinchuk Mikhail M
Winkler Andrea S AS
Study Outcome
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