Childhood, adolescent and adult age at onset and related clinical correlates in obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS).
Journal: International journal of psychiatry in clinical practice
Volume: 20
Issue: 4
Year of Publication: 2017
Affiliated Institutions:
a Department of Neuroscience and Mental Health , University of Milan, Fondazione IRCCS Ca'Granda , Ospedale Maggiore Policlinico , Milano , Italy ;
c Department of Psychiatry and Behavioral Sciences , Albert Einstein College of Medicine and Montefiore Medical Center , New York , USA ;
d Mental Health Unit , Hertfordshire Partnership Foundation Trust, Queen Elizabeth II Hospital , Welwyn Garden City , UK ;
e Department of Psychiatry and Mental Health, MRC Unit on Anxiety and Stress Disorders , University of Cape Town , Cape Town , South Africa ;
f Department of Psychiatry, MRC Unit on Anxiety and Stress Disorders , University of Stellenbosch , Stellenbosch , South Africa ;
g Carracci Medical Group , Mexico City , Mexico ;
h Dipartimento Di Psichiatria, Neurobiologia, Farmacologia E Biotechnologie , Università Di Pisa , Italy ;
i Department of Psychiatry , University of Florence, and Institute of Neurosciences , Florence , Italy ;
j Department of Psychiatry and Behavioural Neurosciences , McMaster University, MacAnxiety Research Center Hamilton , Canada ;
k Department of Psychiatry , Sisli Eftal Teaching and Research Hospital , Istanbul , Turkey ;
l National and Trustwide Services for OCD/BDD, SW London and St George's NHS Trust , London ;
m University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum , Sofia , Bulgaria ;
n Department of Psychiatry , Academic Medical Center , Amsterdam , the Netherlands ;
o Department of Psychiatry and Behavioral Neuroscience , University of Chicago, Pritzker School of Medicine , Chicago , IL , USA ;
p National Post-Trauma Center , Research Foudation by the Sheba Medical Center , Israel ;
q Department of Psychiatry , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands ;
r Department of Psychiatry , Hospital Universitari De Bellvitge-IDIBELL, University of Barcelona, Cibersam , Barcelona , Spain.
Abstract summary
Many studies suggest that age at onset (AAO) is an important factor for clinically differentiating patients with juvenile and adult onset of obsessive-compulsive disorder (OCD). The present international study aimed to assess the prevalence of different AAO groups and compare related socio-demographic and clinical features in a large sample of OCD patients.A total of 431 OCD outpatients, participating in the ICOCS network, were first categorised in groups with childhood (≤12 years), adolescent (13-17 years) and adult-onset (≥18 years), then in pre-adult and adult onset (≥18 years) and their socio-demographic and clinical features compared.Twenty-one percent (n = 92) of the sample reported childhood onset, 36% (n = 155) adolescent onset, and 43% (n = 184) adult onset. Patients with adult onset showed a significantly higher proportion of females compared with the other subgroups (χ(2 )=( )10.9, p< 0.05). Childhood- and adolescent-onset patients had been more frequently treated with cognitive behavioural therapy (CBT), compared to adult-onset patients (χ(2 )=( )11.5; p < 0.05). The pre-adult- versus adult-onset analysis did not show any additional significant difference.The present international multicentre study confirms that OCD onset occurs more frequently before adult age, with approximately one out of five patients showing childhood onset. Pre-adult onset was associated with higher rate of CBT, while adult onset was more prevalent in females.
Authors & Co-authors:
Dell'Osso Bernardo B
Benatti Beatrice B
Hollander Eric E
Fineberg Naomi N
Stein Dan J DJ
Lochner Christine C
Nicolini Humberto H
Lanzagorta Nuria N
Palazzo Carlotta C
Altamura A Carlo AC
Marazziti Donatella D
Pallanti Stefano S
Van Ameringen Michael M
Karamustafalioglu Oguz O
Drummond Lynne M LM
Hranov Luchezar L
Figee Martijn M
Grant Jon E JE
Zohar Joseph J
Denys Damiaan D
Menchon Jose M JM
Study Outcome
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