Multi-vendor standardized sequence for edited magnetic resonance spectroscopy.

Journal: NeuroImage

Volume: 189

Issue: 

Year of Publication: 2020

Affiliated Institutions:  Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: msaleh@jhmi.edu. Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa; Department of Nuclear Engineering, University of Tripoli, Tripoli, Libya. Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. GE Healthcare, Berlin, Germany. Canon Medical Research USA, Mayfield Village, OH, USA. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway. Department of Clinical Radiology, Haukeland University Hospital, Bergen, Norway; Department of Physics and Technology, University of Bergen, Norway. Siemens Healthineers, USA.

Abstract summary 

Spectral editing allows direct measurement of low-concentration metabolites, such as GABA, glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho)physiology. The most widely used spectral editing technique is MEGA-PRESS, which has been diversely implemented across research sites and vendors, resulting in variations in the final resolved edited signal. In this paper, we describe an effort to develop a new universal MEGA-PRESS sequence with HERMES functionality for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes and timings. New RF pulses were generated for the universal sequence. Phantom experiments were conducted on Philips, Siemens, GE and Canon 3 T MRI scanners using 32-channel head coils. In vivo experiments were performed on the same six subjects on Philips and Siemens scanners, and on two additional subjects, one on GE and one on Canon scanners. On each platform, edited MRS experiments were conducted with the vendor-native and universal MEGA-PRESS sequences for GABA (TE = 68 ms) and Lac editing (TE = 140 ms). Additionally, HERMES for GABA and GSH was performed using the universal sequence at TE = 80 ms. The universal sequence improves inter-vendor similarity of GABA-edited and Lac-edited MEGA-PRESS spectra. The universal HERMES sequence yields both GABA- and GSH-edited spectra with negligible levels of crosstalk on all four platforms, and with strong agreement among vendors for both edited spectra. In vivo GABA+/Cr, Lac/Cr and GSH/Cr ratios showed relatively low variation between scanners using the universal sequence. In conclusion, phantom and in vivo experiments demonstrate successful implementation of the universal sequence across all four major vendors, allowing editing of several metabolites across a range of TEs.

Authors & Co-authors:  Saleh Muhammad G MG Rimbault Daniel D Mikkelsen Mark M Oeltzschner Georg G Wang Anna M AM Jiang Dengrong D Alhamud Ali A Near Jamie J Schär Michael M Noeske Ralph R Murdoch James B JB Ersland Lars L Craven Alexander R AR Dwyer Gerard Eric GE Grüner Eli Renate ER Pan Li L Ahn Sinyeob S Edden Richard A E RAE

Study Outcome 

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Statistics
Citations :  Bonavita S, Di Salle F, Tedeschi G. 1999. Proton MRS in neurological disorders. Eur J Radiol. 30:125–131.
Authors :  18
Identifiers
Doi : 10.1016/j.neuroimage.2019.01.056
SSN : 1095-9572
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Edited MRS;HERMES;MEGA-PRESS;Magnetic resonance spectroscopy;Standardization
Study Design
Study Approach
Country of Study
Publication Country
United States