Abstract summary 

Immature female guinea pigs are relatively insensitive to the effects of ovarian steroids on certain reproductive processes including the facilitation of sexual receptivity and the induction of hypothalamic progestin receptors by estrogen. In adult guinea pigs, alpha-receptor-mediated noradrenergic transmission is known to affect both of these processes. In the experiments reported here, we investigated the possibility that age-related differences in alpha 1- and alpha 2-noradrenergic receptors might underlie the insensitivity of neonates to ovarian steroids. With tritium-sensitive film autoradiography, the distribution of alpha 1- and alpha 2-receptors in neonatal and adult female guinea pigs was compared and the effects of exogenous estradiol-17 beta on alpha-receptor binding was examined in neonatal guinea pigs. The results of these experiments showed that in animals not treated with estrogen the binding of both alpha-receptor subtypes differed between adults and neonates in several brain regions including areas known to be involved in the regulation of reproduction. In all regions where differences occurred, alpha-receptor levels were higher in neonatal females than in adult females. In addition, in contrast to previously reported results in adults, estrogen did not affect alpha-receptor binding in any region of neonatal guinea pig brain.

Authors & Co-authors:  Johnson A E AE Nock B B McEwen B S BS Feder H H HH

Study Outcome 

Source Link: Visit source