Abstract summary 

The ontogenetic development of 'central' and 'peripheral' benzodiazepine (BZ) receptors was investigated in 3 different regions of the guinea pig brain. A marked difference in the developmental profile of these two types of binding sites was observed. The density of central-type receptors gradually increased during embryonic life (especially in cortex and cerebellum), without major changes after birth, while the reverse was true for peripheral-type binding sites. These data contrast with those previously reported in rat, suggesting species differences.

Authors & Co-authors:  Daval J L JL Deckert J J Nakajima T T Morgan P F PF Marangos P J PJ

Study Outcome 

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