Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
Journal: Twin research and human genetics : the official journal of the International Society for Twin Studies
Volume: 18
Issue: 5
Year of Publication: 2016
Affiliated Institutions: Department of Social Research,University of Helsinki,Helsinki,Finland. Department of Public Health Nursing,Osaka City University,Osaka,Japan. Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan. Department of Public Health,University of Helsinki,Helsinki,Finland. Department of Noncommunicable Diseases Prevention,Qingdao Centers for Disease Control and Prevention,Qingdao,China. Department of Human Anatomy and Psychobiology,University of Murcia,Murcia,Spain. Department of Developmental and Educational Psychology,University of Murcia,Murcia,Spain. Michigan State University,East Lansing,MI,USA. QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. Department of Psychology,Bielefeld University,Bielefeld,Germany. MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK. Department of Psychology,Goldsmiths,University of London,New Cross,London,UK. Department of Psychological and Brain Sciencies,Boston University,Boston,MA,USA. School of Epidemiology,Public Health and Preventive Medicine,University of Ottawa,Ottawa,Ontario,Canada. École de psychologie,Université Laval,Québec,Canada. Department of Radiology and Oncotherapy,Semmelweis University,Budapest,Hungary. MRC Integrative Epidemiology Unit,University of Bristol,Bristol,UK. Department of Statistics,Faculty of Arts and Sciences,Kırıkkale University,Kırıkkale,Turkey. Departments of Psychiatry,Psychology,and Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA. Istituto Superiore di Sanità - National Center for Epidemiology,Surveillance and Health Promotion,Rome,Italy. Murdoch Childrens Research Institute,Royal Children's Hospital,Melbourne,Victoria,Australia. Institute of Research & Development,Battaramulla,Sri Lanka. NIHR Mental Health Biomedical Research Centre,South London and Maudsley NHS Foundation Trust, andInstitute of Psychiatry Psychology and Neuroscience,King's College London,London,UK. Department of Twin Research and Genetic Epidemiology,King's College London,London,UK. Department of Psychology,University of Southern California,Los Angeles,CA,USA. Institute of Medicine,National Academy of Sciences Washington,DC,WA,USA. Healthy Twin Association of Mongolia,Ulaanbaatar,Mongolia. Graduate School of Biomedical and Health Sciences,Hiroshima University,Hiroshima,Japan. Department of Physical Education and Sport,University of Madeira,Funchal,Portugal. CIFID,Faculty of Sport,University of Porto,Porto,Portugal. Department of Psychology,University of Texas at Austin,Austin,TX,USA. Department of Psychology,Pusan National University,Busan,SouthKorea. The Danish Twin Registry,Institute of Public Health,Epidemiology,Biostatistics & Biodemography,University of Southern Denmark,Odense,Denmark. Department of Clinical Research,University of Southern Denmark,Odense,Denmark. Centre of Human Genetics,University Hospitals Leuven,Leuven,Belgium. The Charles Bronfman Institute for Personalized Medicine,The Mindich Child Health and Development Institute,Icahn School of Medicine at Mount Sinai,New York,NY,USA. Department of Preventive Medicine,Keck School of Medicine of USC,University of Southern California,Los Angeles,CA,USA. State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou,China. Department of Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA. Department of Human and Molecular Genetics,Psychiatry & Massey Cancer Center,Virginia Commonwealth University,Richmond,VA,USA. The Australian Twin Registry,Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia. Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia. Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden. Department of Family Medicine,Samsung Medical Center,School of Medicine,Sungkyunkwan University,Seoul,South Korea. Department of Epidemiology,School of Public Health,Seoul National University,Seoul,SouthKorea. Department of Family Medicine,Busan Paik Hospital,Inje University College of Medicine,Busan,South Korea. Bandim Health Project,INDEPTH Network,Bissau,Guinea-Bissau. Department of Endocrinology,Odense University Hospital,Odense,Denmark. Department of Infectious Diseases,Odense University Hospital,Odense,Denmark. Epidemiology,Biostatistics and Biodemography,Institute of Public Health,University of Southern Denmark,Odense,Denmark. Department of Public Health,Qingdao University Medical College,Qingdao,China. Department of Medicine,Stanford Prevention Research Center,Stanford University School of Medicine,Stanford,CA,USA. Center for Health Sciences,SRI International,Menlo Park,CA,USA. Department of Psychiatry,University of British Columbia,Vancouver,British Columbia,Canada. The Hebrew University of Jerusalem,Jerusalem,Israel. Department of Obstetrics and Gynecology,Hadassah Hospital,Hebrew University Medical School,Jerusalem,Israel. Department of Psychology,University of Minnesota,Minneapolis,MN,USA. Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden. Center for Clinical and Epidemiological Research,University of Washington,Seattle,WA,USA. Institute for Behavioral Genetics,Boulder,CO,USA. Department of Health and Exercise Sciences and Colorado School of Public Health,Colorado State University,CO,USA. Psychology and Neuroscience,Duke University,Durham,NC,USA. Department of Psychiatry,University of California,San Diego,CA,USA. Department of Psychology,Boston University,Boston,MA,USA. Department of Health Science,Ishikawa Prefectural Nursing University,Kahoku,Ishikawa,Japan. Department of Genes and Environment,Division of Epidemiology,Norwegian Institute of Public Health,Oslo,Norway. Faculty of Health Science,Kio University,Nara,Japan. Department of Biological Psychology,VU University Amsterdam,Amsterdam,The Netherlands. Department of Epidemiology and Public Health,Health Behaviour Research Centre,Institute of Epidemiology and Health Care,University College London,London,UK. Department of Genetics,Physical Anthropology and Animal Physiology,University of the Basque Country UPV/EHU,Leioa,Spain. HealthTwiSt GmbH,Berlin,Germany. Department of Epidemiology,School of Public Health,University of Washington,Seattle,WA,USA. Department of Education,Mokpo National University,Jeonnam,South Korea. Section on Metabolic Genetics,Novo Nordisk Foundation Centre for Basic Metabolic Research,Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark.
Abstract summary
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.Authors & Co-authors: Jelenkovic Aline A Yokoyama Yoshie Y Sund Reijo R Honda Chika C Bogl Leonie H LH Aaltonen Sari S Ji Fuling F Ning Feng F Pang Zengchang Z Ordoñana Juan R JR Sánchez-Romera Juan F JF Colodro-Conde Lucia L Burt S Alexandra SA Klump Kelly L KL Medland Sarah E SE Montgomery Grant W GW Kandler Christian C McAdams Tom A TA Eley Thalia C TC Gregory Alice M AM Saudino Kimberly J KJ Dubois Lise L Boivin Michel M Tarnoki Adam D AD Tarnoki David L DL Haworth Claire M A CM Plomin Robert R Öncel Sevgi Y SY Aliev Fazil F Stazi Maria A MA Fagnani Corrado C D'Ippolito Cristina C Craig Jeffrey M JM Saffery Richard R Siribaddana Sisira H SH Hotopf Matthew M Sumathipala Athula A Rijsdijk Fruhling F Spector Timothy T Mangino Massimo M Lachance Genevieve G Gatz Margaret M Butler David A DA Bayasgalan Gombojav G Narandalai Danshiitsoodol D Freitas Duarte L DL Maia José Antonio JA Harden K Paige KP Tucker-Drob Elliot M EM Kim Bia B Chong Youngsook Y Hong Changhee C Shin Hyun Jung HJ Christensen Kaare K Skytthe Axel A Kyvik Kirsten O KO Derom Catherine A CA Vlietinck Robert F RF Loos Ruth J F RJ Cozen Wendy W Hwang Amie E AE Mack Thomas M TM He Mingguang M Ding Xiaohu X Chang Billy B Silberg Judy L JL Eaves Lindon J LJ Maes Hermine H HH Cutler Tessa L TL Hopper John L JL Aujard Kelly K Magnusson Patrik K E PK Pedersen Nancy L NL Aslan Anna K Dahl AK Song Yun-Mi YM Yang Sarah S Lee Kayoung K Baker Laura A LA Tuvblad Catherine C Bjerregaard-Andersen Morten M Beck-Nielsen Henning H Sodemann Morten M Heikkilä Kauko K Tan Qihua Q Zhang Dongfeng D Swan Gary E GE Krasnow Ruth R Jang Kerry L KL Knafo-Noam Ariel A Mankuta David D Abramson Lior L Lichtenstein Paul P Krueger Robert F RF McGue Matt M Pahlen Shandell S Tynelius Per P Duncan Glen E GE Buchwald Dedra D Corley Robin P RP Huibregtse Brooke M BM Nelson Tracy L TL Whitfield Keith E KE Franz Carol E CE Kremen William S WS Lyons Michael J MJ Ooki Syuichi S Brandt Ingunn I Nilsen Thomas Sevenius TS Inui Fujio F Watanabe Mikio M Bartels Meike M van Beijsterveldt Toos C E M TC Wardle Jane J Llewellyn Clare H CH Fisher Abigail A Rebato Esther E Martin Nicholas G NG Iwatani Yoshinori Y Hayakawa Kazuo K Sung Joohon J Harris Jennifer R JR Willemsen Gonneke G Busjahn Andreas A Goldberg Jack H JH Rasmussen Finn F Hur Yoon-Mi YM Boomsma Dorret I DI Sørensen Thorkild I A TI Kaprio Jaakko J Silventoinen Karri K
Study Outcome
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Citations : Antoniades L, MacGregor AJ, Andrew T, Spector TD. Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford, England) 2003;42:791–796.Authors : 130
Identifiers
Doi : 10.1017/thg.2015.57SSN : 1832-4274