Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression.

Journal: Psychiatry research

Volume: 288

Issue: 

Year of Publication: 2020

Affiliated Institutions:  Department of Neuroscience, University of Calgary, Calgary, AB, Canada. Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia. Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Electronic address: chad.bousman@ucalagary.ca.

Abstract summary 

Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.

Authors & Co-authors:  Savadlou Aisouda A Arnatkeviciute Aurina A Tiego Jeggan J Hawi Ziarih Z Bellgrove Mark A MA Fornito Alex A Bousman Chad C

Study Outcome 

Source Link: Visit source

Statistics
Citations : 
Authors :  7
Identifiers
Doi : 10.1016/j.psychres.2020.112984
SSN : 1872-7123
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
CYP2C19;Hippocampus;Metabolism
Study Design
Study Approach
Country of Study
Publication Country
Ireland