Reporting of clozapine-induced gastrointestinal hypomotility and factors associated with fatal outcomes in Canada: A pharmacovigilance database study.

Journal: Psychiatry research

Volume: 290

Issue: 

Year of Publication: 2020

Affiliated Institutions:  Alberta Innovates Heritage Youth Researcher Summer Program, University of Calgary, Calgary, AB, Canada. Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada. Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Psychiatry, University of Calgary, Calgary, AB, Canada; Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada; Department of Medical Genetics, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Electronic address: chad.bousman@ucalagary.ca.

Abstract summary 

Clozapine-induced gastrointestinal hypomotility (CIGH) is poorly understood and potentially life-threatening. Herein, we present trends of CIGH annual reporting and explore factors associated with a fatal outcome using 25-years of pharmacovigilance data in Canada. Since 1993, the number of CIGH reports increased 22-fold but the proportion of fatal reports remained relatively stable. Fatal reports of CIGH were associated with older age but not sex, clozapine dose, or clozapine duration. Concomitant use of medications used to treat CIGH (lactulose, docusate sodium) and its associated pain/discomfort (acetaminophen, lorazepam) were more commonly reported in fatal cases. Confirmatory and prospective studies of CIGH are warranted.

Authors & Co-authors:  Liu Cecilia L CL Maruf Abdullah Al AA Bousman Chad A CA

Study Outcome 

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Statistics
Citations : 
Authors :  3
Identifiers
Doi : 10.1016/j.psychres.2020.113048
SSN : 1872-7123
Study Population
Male,Female
Mesh Terms
Adult
Other Terms
Canada;Clozapine;Gastrointestinal Hypomotility
Study Design
Study Approach
Country of Study
Publication Country
Ireland