Analysis of Cutaneous Lupus Hospitalizations: A United States National Population-Based Study.

Journal: Cureus

Volume: 15

Issue: 5

Year of Publication: 

Affiliated Institutions:  Internal Medicine, Loma Linda University Medical Center, Loma Linda, USA. School of Medicine, University of Missouri School of Medicine, Columbia, USA. Internal Medicine, Springfield Clinic, Lincoln, USA. Internal Medicine, University of Benin Teaching Hospital, Benin City, NGA. Medicine, University of Mississippi Medical Center, Jackson, USA. Dermatology Clinical Research, University of California San Diego, San Diego, USA. Internal Medicine, University of Benin/Kazaure General Hospital, Kazaure, NGA. Gastroenterology, Spire Manchester Hospital, Manchester, GBR. Internal Medicine, University of Benin College of Medicine, Benin City, NGA. Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Abstract summary 

Background There are limited studies analyzing cutaneous lupus erythematosus (CLE) hospitalizations. In this study, we aimed to analyze baseline demographics of systemic lupus erythematosus (SLE) and CLE patients, identify the most common reasons for hospitalizations, and find out the hospitalization outcomes.  Materials and methods We performed the analysis using the National (Nationwide) Inpatient Sample (NIS) database between 2016 and 2019. For the CLE cohort, data for adults aged 18 years and older with the primary or secondary diagnosis of CLE using International Classification of Disease - 10th revision (ICD-10) codes were extracted. For comparison, the SLE cohort was identified by patients aged 18 years and older with primary or secondary diagnoses of SLE using ICD-10 codes. Chi-squared test was used to compare baseline demographic characteristics. Multivariable logistic and linear regression was used to calculate outcomes of interest. Results In comparison to the SLE cohort, the CLE cohort was not only older in age and lower percentage female, but also had shorter length of stay, less total hospital charge, and the majority had Medicare as primary insurance. The SLE cohort included predominantly African American patients while the CLE cohort was majority Caucasian patients. The cardiovascular risks were more prevalent in the CLE cohort and most commonly admitted for sepsis, cardiovascular disease, and mental health disorders. Conclusion Our study highlights the importance of outpatient follow-up in CLE patients to closely monitor cardiovascular risk factors, early identification of infections, and routine mental health screenings to reduce hospitalizations and resource utilization.

Authors & Co-authors:  He Emily E Hino Christopher C Aihie Osaigbokan O Ijeli Anthonia A Ugoh Amaka C AC Akhlaq Anum A Osuoji Olive C OC Eboma John J Ezomo Joan J Onobraigho Precious P Eseaton Precious O PO Edigin Ehizogie E

Study Outcome 

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Citations :  Epidemiology of cutaneous lupus erythematosus in a tertiary referral centre in Singapore. Ng PP, Tan SH, Koh ET, Tan T. Australas J Dermatol. 2000;41:229–233.
Authors :  12
Identifiers
Doi : e38982
SSN : 2168-8184
Study Population
Male,Female
Mesh Terms
Other Terms
cutaneous lupus erythematous;hospital resource utilization;inpatient mortality ;national population-based study;rheumatology;systemic lupus erythematous;trend analysis
Study Design
Study Approach
Country of Study
Publication Country
United States