Psychiatric Disorders in Adolescents Living with HIV and Association with Antiretroviral Therapy Adherence in Sub-Saharan Africa: A Systematic Review and Meta-analysis.

Journal: AIDS and behavior

Volume: 25

Issue: 6

Year of Publication: 2021

Affiliated Institutions:  Department of Psychiatry, Faculty of Medicine, University of Botswana, Gaborone, Botswana. olawaleanthonya@gmail.com. Department of Psychiatry, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. Clinical Services, Federal Neuropsychiatric Hospital, Benin City, Edo State, Nigeria. KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Abstract summary 

In sub-Saharan Africa (SSA), a systematic approach to exploring the prevalence of psychiatric disorders (PDs) and adherence to antiretroviral treatment (ART) in adolescents living with HIV (ALWHIV) is lacking. This study aimed to systematically review the studies conducted in SSA on the prevalence of PDs among ALWHIV and their association with ART adherence. A systematic search of all English studies assessing PDs among ALWHIV using the Web of Science, PubMed, and EBSCO databases was conducted between March 1 and September 30, 2019. Forty-two studies published between 2009 to 2019 met the inclusion criteria, of which 15 were included in the meta-analysis. The most common PDs were depression (0.24, 95% CI 0.14-0.36) and anxiety disorder (0.26, 95% CI 2-0.44). The available evidence could not conclude on the definitive association between PDs and ART adherence; therefore, further research is required. However, the need for mental health integration in the care for ALWHIV is evident.

Authors & Co-authors:  Olashore Paruk Akanni Tomita Chiliza

Study Outcome 

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Statistics
Citations :  Benton TD, Ifeagwu JA. HIV in adolescents: What we know and what we need to know. Curr Psychiatry Rep. 2008;10(2):109.
Authors :  5
Identifiers
Doi : 10.1007/s10461-020-03100-z
SSN : 1573-3254
Study Population
Male,Female
Mesh Terms
Adolescent
Other Terms
Adherence;Adolescents;HIV;Psychiatric disorders;Sub-Saharan Africa
Study Design
Study Approach
Country of Study
Publication Country
United States