Shared heritability and functional enrichment across six solid cancers.

Journal: Nature communications

Volume: 10

Issue: 1

Year of Publication: 2019

Affiliated Institutions:  Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Huntington Ave, Boston, MA, , USA. xiajiang@hsph.harvard.edu. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Huntington Ave, Boston, MA, , USA. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Eucid Avenue, Cleveland, OH, , USA. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Magnolia Dr. MRC-CANCONT, Tampa, FL, , USA. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Worts' Causeway, Cambridge, CB RN, UK. Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, Medical Center Drive, Lebanon, NH, , USA. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Worts' Causeway, Cambridge, CB RN, UK. Genetic Epidemiology Group, International Agency for Research on Cancer, Cours Albert Thomas, , Lyon, France. Division of Psychiatry, University College London, Maple House, Tottenham Court Road, London, WT NF, UK. Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, , USA. Public Health Sciences, University of Virginia, P.O. Box , Charlottesville, VI, , USA. Epidemiology Research Program, American Cancer Society, Williams Street NW, Atlanta, GA, , USA. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Fairview Ave. N., Seattle, WA, -, USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Medical Center Dr, Rockville, MD, , USA. Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Oxford House, Nashville, TN, , USA. Department of Neurology, Dartmouth-Hitchcock Medical Center, Rubin Building, Room , One Medical Center Drive, Lebanon, NH, , USA. Fred ALitwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University Avenue, Toronto, ON, MGX, Canada. Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine Hall, Irvine, CA, , USA. NNAlexandrov Research Institute of Oncology and Medical Radiology, Settlement of Lesnoy-, , Minsk, Belarus. Markey Cancer Center, University of Kentucky, Rose Street, cc, Lexington, KY, , USA. Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Stuart Street, Kingston, ON, KL N, Canada. Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Pressler St, Houston, TX, , USA. Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, Little Albany Street, Room , New Brunswick, NJ, , USA. Department of Pathology, Landspitali University Hospital, Hringbraut, Reykjavik, , Iceland. Australian Prostate Cancer Research Centre-Qld, Translational Research Institute, Kent St, Woolloongabba, QLD, , Australia. Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen Nuremberg, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Universitaetsstrasse -, , Erlangen, Germany. Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández Almagro, , , Madrid, Spain. Department of Obstetrics and Gynecology, Duke University Medical Center, Morris Bldg, Durham, NC, , USA. Department of Genetic Epidemiology, University Medical Center Goettingen, Humboldtallee , , Goettingen, Germany. Department of Oncology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu , , Helsinki, Finland. Fondazione Policlinico Universitario A. Gemelli IRCCS, , Roma, Italy. Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev Ringvej , , Herlev, Denmark. DrMargarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr, , Stuttgart, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld , , Heidelberg, Germany. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, CB RE, Cambridge, UK. Division of Genetics and Epidemiology, The Institute of Cancer Research, Cotswold Road, London, SM NG, UK. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, AvFrança s/n, , Girona, Spain. Clinical Sciences, Lund University, Box , , Lund, Sweden. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, , Australia. Department of Obstetrics and Gynecology, University of Heidelberg, Im Neuenheimer Feld , , Heidelberg, Germany. Department of Pathology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki th floor, Haartmaninkatu , , Helsinki, Finland. Medical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Calle del Prof Martín Lagos, , Madrid, Spain. Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, via Roma , , Pisa, Italy. Peter MacCallum Cancer Center, Grattan Street, Melbourne, VIC, , Australia. Sorbonne Université, GRC N° ONCOTYPE-URO, Tenon Hospital, , Paris, France. Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, , USA. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld , , Heidelberg, Germany. Molecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte Villela, , Barretos, SP, -, Brazil. Division of Gastroenterology, Massachusetts General Hospital, Fruit Street, Boston, MA, , USA. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, WA, , USA. Centre for Medical Genetics, Ghent University, De Pintelaan , , Gent, Belgium. Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, , Belgium. Department of Clinical Genetics, Erasmus University Medical Center, Wytemaweg , , Rotterdam, CN, The Netherlands. University of Puerto Rico Medical Sciences Campus and Comprehensive Cancer Center, San Juan, PR, , USA. Department of Laboratory Medicine and Pathology, Mayo Clinic, First StSW, Rochester, MN, , USA. Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Western Bank, Sheffield, S TN, UK. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, ulUnii Lubelskiej , -, Szczecin, Poland. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska Univ Hospital, , Stockholm, Sweden. Department of Clinical Genetics, Fox Chase Cancer Center, Cottman Ave, Philadelphia, PA, , USA. Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Hawkesbury Rd, Sydney, NSW, , Australia. Department of Pathology, Leiden University Medical Center, Albinusdreef , ZA, Leiden, The Netherlands. Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Passeig de la Vall d'Hebron -, , Barcelona, Spain. Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Travesía da Choupana S/N, , Santiago de Compostela, Spain. School of Social and Community Medicine, University of Bristol, Bristol, BS TH, UK. Gynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Straße , , Hannover, Germany. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), AvGran Via -, L'Hospitalet de Llobregat, , Barcelona, Spain. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, Regent Street, London, WB HW, UK. Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, SO YD, UK. Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, , USA. Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, West End Avenue, Suite , Nashville, TN, , USA. Department of Cancer Epidemiology, Clinical Sciences, Lund University, Barngatan , Skånes universitetssjukhus, , Lund, Sweden. Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, University of Manchester, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester, M WL, UK. Department of Otolaryngology, UPMC Hillman Cancer Center, Cancer Pavilion, University of Pittsburgh, Suite , Centre Avenue, Pittsburgh, PA, , USA. Molecular and Clinical Cancer Medicine, Roy Castle Lung Cancer Research Programme, The University of Liverpool Institute of Translational Medicine, The Wiliam Duncan Building, West Derby Street, Liverpool, L BX, UK. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Beverly Boulevard, Los Angeles, CA, , USA. The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Old Brompton Road, London, SW RP, UK. Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Neapoleos , AgParaskevi, Athens, , Greece. Section of Infections, International Agency for Research on Cancer, cours Albert Thomas, , Lyon, France. The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Emek HaEla St , , Ramat Gan, Israel. Department of Surgery, Mount Sinai Hospital, University Avenue, Toronto, ON, MG X, Canada. Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Centre, UCLA, Charles Young Drive South, Los Angeles, CA, -, USA. Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Brookline Avenue, Boston, MA, , USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Zonal Ave, Los Angeles, CA, , USA. Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, St Kilda Road, Melbourne, VIC, , Australia. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd, Kansas City, KS, , USA. Department of Medicine, McGill University, Decarie Boulevard, Montréal, QC, HAJ, Canada. Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Circle of Hope, Salt Lake City, UT, , USA. Department of Health Sciences Research, Mayo Clinic, First StSW, Rochester, MN, , USA. Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Beverly Blvd, Room S, Los Angeles, CA, , USA. Public Health Sciences Division, Swedish Cancer Institute, Madison StSte , Seattle, WA, , USA. Unit of Clinical Chemistry, Department of Medical Biosciences, Umeå University, By M van , Sjukhusomradet, Umea universitet, , Umea, Sweden. Clinical Genetics Branch, National Cancer Institute, DCEG, Medical Center Dr, Bethesda, MD, -, USA. Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, , Villejuif, France. Department of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Nobels väg , SE- , SE-, Stockholm, Sweden. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld , , Heidelberg, Germany. Nuffield Department of Surgical Sciences, Faculty of Medical Science, John Radcliffe Hospital, University of Oxford, Oxford, OX JD, UK. Department of Surgical Oncology, Princess Margaret Cancer Centre, University Avenue, Toronto, Ontario, MGM, Canada. Department of Internal Medicine , University Hospital Dresden, Technische Universität Dresden (TU Dresden), , Dresden, Germany. National Institute of Occupational Health (STAMI), Gydas vei , , Oslo, Norway. Department of Gynecology and Gynecologic Oncology, DrHorst Schmidt Kliniken Wiesbaden, Ludwig-Erhard-Straße , , Wiesbaden, Germany. Early Detection and Prevention Section, International Agency for Research on Cancer, cours Albert Thomas, , Lyon, France. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld , , Heidelberg, Germany. Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden , DK-, Copenhagen, Denmark. Preventive Medicine, Seoul National University College of Medicine, Gwanak-ro, Gwanak-gu, Seoul, , Korea. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Level , Swanston Street, Melbourne, VIC, , Australia. German Research Center for Environmental Health, Institute for Cancer Research, Ingolstadter Landstr, London, SM NG, UK. Center for Medical Genetics, NorthShore University HealthSystem, Central St, Evanston, IL, , USA. Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Huntington Ave, Boston, MA, , USA. British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, BC Cancer Agency and University of British Columbia, #- West th Avenue, Vancouver, BC, VZ E, Canada. NNPetrov Institute of Oncology, Leningradskaya ul, , StPetersburg, Russia, . Lombardi Comprehensive Cancer Center, Georgetown University, Reservoir Road, Washington, DC, , USA. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Grattan Street, Melbourne, VIC, , Australia. Section of Genetics, International Agency for Research on Cancer, cours Albert Thomas, , Lyon, France. Department of Radiation Sciences, Umeå University, By M van , Sjukhusomradet, Umea universitet, , Umea, Sweden. Department of Medicine, Division of Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Welch Rd, Stanford, CA, , USA. Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, , Bulgaria. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Beverly Boulevard, Los Angeles, CA, , USA. Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, President Street Bioengineering Building, MSC, Charleston, SC, , USA. Cancer Epidemiology, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistraße , , Hamburg, Germany. Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Worts' Causeway, Cambridge, CB RN, UK. Department of Genetics and Fundamental Medicine, Bashkir State University, ulZaki Validi , Ufa, Russia, . Division of Urologic Surgery, Brigham and Womens Hospital, Boston, Massachusettes, , USA. Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein , EZ, Nijmegen, The Netherlands. Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Pressler St, Houston, TX, , USA. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Murray Street, Toronto, Ontario, MT L, Canada. Biomedical Network on Rare Diseases (CIBERER), AvMonforte de Lemos, -Pabellón Planta , , Madrid, Spain. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, National Institutes of Health, Medical Center Dr, Bethesda, MD, , USA. Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Ullernchausseen , , Oslo, Norway. Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Institute - Oncology Center, Roentgena , -, Warsaw, Poland. Head and Neck Surgery, Department of Otorhinolaryngology, Maastricht University Medical Center, PDebyelaan , POBox , AZ, Maastricht, The Netherlands. Department of Integrative Oncology, British Columbia Cancer Agency, Room - West th Avenue, Vancouver, BC, VZL, Canada. VIB Center for Cancer Biology, VIB, Herestraat , , Leuven, Belgium. Integrative Tumor Epidemiology Branch, DCEG, National Cancer Institute, Medical Center Drive, Room SG/E, Rockville, MD, , USA. College of Pharmacy, Washington State University, PBS PO Box , Spokane, WA, -, USA. Cancer Control Research, BC Cancer Agency, West th Avenue, Vancouver, BC, VZ L, Canada. Clalit Health Services, Clalit National Israeli Cancer Control Center, Carmel Medical Center, Horev Street, , Haifa, Israel. Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Martinistraße , , Hamburg, Germany. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, York Avenue, New York, NY, , USA. Department of Family Medicine and Community Health, Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, OH, , USA. Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, , USA. Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska Univ Hospital, , Stockholm, Sweden. Health Sciences Research, Mayo Clinic Arizona, EShea Blvd, Scottsdale, AZ, , USA. Epidemiology Division, Princess Margaret Cancer Centre, University Avenue, Toronto, ON, MGM, Canada. Unit of Oncology , Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IRCCS, , Padua, Italy. Department of Medical Genetics, Oslo University Hospital, Kirkeveien , , Oslo, Norway. Institute of Human Genetics, University Hospital Ulm, Prittwitzstrasse , , Ulm, Germany. Translational Cancer Research Area, University of Eastern Finland, Yliopistonranta , , Kuopio, Finland. Epidemiology Program, University of Hawaii Cancer Center, Ilalo St, Honolulu, HI, , USA. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, , Sweden. Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, University Avenue, OPG Wing, -, Toronto, ON, MG M, Canada. Division of Gynaecology and Obstetrics, , Technische Universität München, Arcisstraße , , Munich, Germany. NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, , USA. Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, , USA. Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Via Gattamelata , Padua, , Italy. Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and University of Barcelona, Barcelona, , Spain. Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY, , USA. Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, M PL, UK. Department of Laboratory Medicine and Pathobiology, University of Toronto, King's College Circle, Toronto, ON, MSA, Canada. Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Civic Center Boulevard, Philadelphia, PA, , USA. NIHR Bristol Biomedical Research Centre Nutrition Theme, University of Bristol, Upper Maudlin Street, Bristol, BS AE, UK. Department of Population Sciences, Beckman Research Institute of City of Hope, E Duarte, Duarte, CA, , USA. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu , , Helsinki, Finland. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej , DK-, Copenhagen, Denmark. Latvian Biomedical Research and Study Centre, Ratsupites str , Riga, LV-, Latvia. Cancer Genetics and Prevention Program, University of California San Francisco, Divisadero St, San Francisco, CA, -, USA. Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, York Avenue, New York, NY, , USA. Department of Molecular Genetics, National Institute of Oncology, Ráth György u-, , Budapest, Hungary. Center for Clinical Cancer Genetics, The University of Chicago, S Maryland Ave, Chicago, IL, , USA. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Dauer Dr, Chapel Hill, NC, -, USA. The University of Surrey, Guildford, Surrey, GU XH, UK. Department of Cancer Epidemiology, HLee Moffitt Cancer Center and Research Institute, Magnolia Drive, Tampa, FL, , USA. Department of Applied Health Research, University College London, - Torrington Place, London, WCE BT, UK. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, , Australia. Department of Obstetrics and Gynecology, Oregon Health & Science University, SW Sam Jackson Park Road, L-, Portland, OR, , USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Longwood Avenue, Boston, MA, , USA. Department of Gastroenterology, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid , Internal BOBox , GA, Nijmegen, The Netherlands. Research Centre for Genetic Engineering and Biotechnology 'Georgi DEfremov', Macedonian Academy of Sciences and Arts, Boulevard Krste Petkov Misirkov, , Skopje, Republic of Macedonia. Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS LY, UK. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Via Giacomo Venezian , , Milan, Italy. Decode genetics, Sturlugata , IS- Reykjavik, Reykjavik, Iceland, Iceland. School of Women's and Children's Health, Faculty of Medicine, University of NSW Sydney, High St, Sydney, NSW, , Australia. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, st Ave S # D, Nashville, TN, , USA. Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Michal Street, , Haifa, Israel. Department of Genetics, University of Pretoria, Private Bag X, Arcadia, , South Africa. Department of Chronic Disease Epidemiology, Yale School of Public Health, College St, New Haven, CT, , USA. Cancer Center Cluster Salzburg at PLUS, Department of Molecular Biology, University of Salzburg, Billrothstr, , Salzburg, Austria. Department of Urology, Erasmus University Medical Center, Wytemaweg , CN, Rotterdam, The Netherlands. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, Madison Avenue, New York, NY, , USA. Faculty of Medicine and Health Sciences, Basic Medical Sciences, Ghent University, De Pintelaan , , Gent, Belgium. Hereditary Cancer Clinic, University Hospital of Heraklion, Voutes, , Heraklion, Greece. Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, TWAlexander Drive, Research Triangle Park, NC, , USA. Research Oncology, Guy's Hospital, King's College London, Guy's Hospital Great Maze Pond, London, SE RT, UK. Institute of Biomedicine, University of Turku, , Turku, Finland. Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Plesmanlaan , CX, Amsterdam, The Netherlands. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Biggy Street, Los Angeles, CA, , USA. Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Longmian Ave, Jiangning District, , Nanjing, People's Republic of China. Department of Genetics and Genomic Sciences, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Madison Avenue, nd floor, New York, NY, , USA. Dept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Waehringer Guertel -, , Vienna, Austria. Department of Internal Medicine, University of Utah Health Sciences Center, Chipeta Way, Salt Lake City, UT, , USA. Department of Molecular Medicine, Aarhus University Hospital, DK-, Aarhus, Denmark. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton Road, Clayton, VIC, , Australia. Department of Medicine III, University Hospital, LMU Munich, Marchioninistr, , Munich, Germany. Department of Obstetrics and Gynecology, Sahlgrenska Cancer Center, Inst Clinical Scienses, University of Gothenburg, Blå stråket , , Gothenburg, Sweden. Epidemiology Center, College of Medicine, University of South Florida, Spectrum Blvd, Suite , Tampa, FL, , USA. Department of Molecular Biology, School of Medicine of São José do Rio Preto, Av Brig Faria Lima Vila São Pedro, São José do Rio Preto, SP, -, Brazil. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, , USA. Faculty of Medicine, University of Oviedo and CIBERESP, Campus del Cristo s/n, , Oviedo, Spain. Medical Statistics Group, School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, Regent Street, Sheffield, S DA, UK. Department of Genetics, Portuguese Oncology Institute, Rua DrAntónio Bernardino de Almeida , -, Porto, Portugal. Department of Epidemiology, Mailman School of Public Health, Columbia University, West th Street, New York, NY, , USA. Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Longwood Avenue RFB , Boston, MA, , USA. Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard , , Odence C, Denmark. Department of Gynecology and Obstetrics, Haukeland University Hospital, , Bergen, Norway. Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Decarie Boulevard, Montréal, QC, HAJ, Canada. Department of Cancer Biology and Genetics, The Ohio State University, Wth Avenue, Columbus, OH, , USA. Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, M GJ, UK. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX LF, UK. Department of Medical Oncology, Beth Israel Deaconess Medical Center, Brookline Avenue, Boston, MA, , USA. Department of Oncology, Cross Cancer Institute, University of Alberta, St & Ave, Edmonton, AB TG R, Canada. Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Herestraat , , Leuven, Belgium. Fundación Pública Galega Medicina Xenómica & Instituto de Investigación Sanitaria de Santiago de Compostela, calle Choupana s/n, , Santiago De Compostela, Spain. Population Health Department, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, QLD, , Australia. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, TWAlexander Drive, Research Triangle Park, NC, , USA. Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, , NC, USA. City of Hope Clinical Cancer Genomics Community Research Network, East Duarte Road, Duarte, CA, , USA. Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre,, The Christie Hospital NHS Foundation Trust, Manchester, M PL, UK. Fred Hutchinson Cancer Research Center, Fairview Ave N, Seattle, WA, , USA. Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Campus Drive, Stanford, CA, , USA. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig Maximilians University, Neuherberg D-, Munich, , Bavaria, Germany. Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Aapistie A, , Oulu, Finland. Academic Unit of Clinical Oncology, University of Sheffield, Weston Park Hospital, Whitham Road, Sheffield, S SJ, UK. Discipline of Genetics, Memorial University of Newfoundland, StJohn's, NL, AC S, Canada. Department of Epidemiology, Division of Cancer Prevention and Population Science, The University of Texas MD Anderson Cancer Center, Holcombe Blvd, Houston, TX, , USA. Magee-Womens Hospital, University of Pittsburgh School of Medicine, Halket St, Pittsburgh, PA, , USA. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Ames St, Cambridge, MA, , USA. Human Genetics, Graduate School of Public Health, University of Pittsburgh, UPMC Cancer Pavilion, Suite C, Office # , Centre Avenue, Pittsburgh, PA, , USA. Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, cours Albert Thomas, , Lyon, France. Department of Epidemiology, University of Washington School of Public Health, NE Pacific St, Seattle, WA, , USA. Genomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Laurier Boulevard, Québec City, QC, GVG, Canada. UCLA Path and Lab Med, University of California, Le Conte Ave, Los Angeles, CA, , USA. Department of Medicine, Epidemiology Section, Institute for Clinical and Translational Research, Baylor Medical College, One Baylor Plaza, MS: BCM, Suite D, Houston, TX, -, USA. Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Huntington Ave, Boston, MA, , USA. pkraft@hsph.harvard.edu. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Fairview Ave. N., Seattle, WA, -, USA. saralind@uw.edu.

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