Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Volume: 120
Issue: 14
Year of Publication: 2023
Affiliated Institutions: Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen XD, The Netherlands. Division of Cerebral Integration, National Institute for Physiological Sciences, Okazaki -, Japan. Department of Pathology of Mental Diseases, National Center of Neurology and Psychiatry, National Institute of Mental Health, Tokyo -, Japan. Department of Psychiatry, University Medical Center Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht CG, The Netherlands. Department of Psychiatry, Instituto de Investigación Marqués de Valdecilla, University Hospital Marqués de Valdecilla, Santander , Spain. Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid , Spain. Department of Radiology, Instituto de Investigación Marqués de Valdecilla, Marqués de Valdecilla University Hospital, Santander , Spain. Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo , Norway. Department of Psychology, University of Oslo, Oslo , Norway. Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD . School of Psychiatry, University of New South Wales, Sydney , Australia. School of Medicine, The University of Queensland, Brisbane , Australia. School of Psychological Sciences, University of Newcastle, Newcastle , Australia. Queensland Brain Institute, The University of Queensland, Brisbane , Australia. Centre for Brain and Mental Health Research, University of Newcastle, Newcastle , Australia. School of Biomedical Science and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle , Australia. School of Medicine and Public Health, University of Newcastle, Newcastle , Australia. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne , Australia. Early Psychosis Department, Department of Psychiatry, Amsterdam UMC (location AMC), Amsterdam AZ, The Netherlands. Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg , Germany. Department of General Psychiatry, Section for Experimental Psychopathology and Neuroimaging, Heidelberg University, Heidelberg , Germany. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA . Department of Psychiatry and Neuroscience, University of New Mexico, Albuquerque, NM . Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, CA . Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA . Psychology Department and Neuroscience Institute, Georgia State University, Atlanta, GA . San Francisco VA Medical Center, University of California, San Francisco, CA . Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing , P.R. China. Chongqing University Three Gorges Hospital, Chongqing , P.R. China. Division of Psychological and Social Medicine and Developmental Neurosciences, Translational Developmental Neuroscience Section, Technische Universität Dresden, University Hospital C.G. Carus, Dresden , Germany. FIDMAG Germanes Hospitalàries Research Foundation, Barcelona , Spain. Laboratory of Neuropsychiatry, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome , Italy. Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht University, Maastricht ER, The Netherlands. Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto MS S, Canada. West Region, Institute of Mental Health, Singapore , Singapore. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE AF, United Kingdom. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE AF, United Kingdom. Department of Psychiatry, Jeonbuk National University Medical School, Jeonju , Republic of Korea. Department of Psychiatry, University Psychiatric Clinics (Universitäre Psychiatrische Kliniken), University of Basel, Basel , Switzerland. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH SB, United Kingdom. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch , South Africa. Institute for Translational Psychiatry, Westfälische Wilhelms-Universität Münster, Münster , Germany. Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck , Germany. The Mind Research Network, Albuquerque, NM . Department of Education, Psychology, Communication, University of Bari Aldo Moro, Bari , Italy. Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari , Italy. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid , Spain. Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow , Russian Federation. Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm , Sweden. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Zurich , Switzerland. National Institute of Mental Health, Klecany , Czech Republic. Department of Neuropsychiatry, Seoul National University Hospital, Seoul , Republic of Korea. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul , Republic of Korea. Department of Psychiatry, Seoul National University College of Medicine, Seoul , Republic of Korea. Department of Psychiatry, University of Oxford, Oxford OX JX, United Kingdom. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main , Germany. Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town , South Africa. Department of Psychiatry, Research Group in Psychiatry (GIPSI), Faculty of Medicine, Universidad de Antioquia, Medellín , Colombia. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen HB, The Netherlands. Department of Psychiatry, Boston Children's Hospital and Harvard Medical School, Boston, MA . Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA . School of Psychology, University of Auckland, Auckland , New Zealand. Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane , Australia. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA .
Abstract summary
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.Authors & Co-authors: Schijven Postema Fukunaga Matsumoto Miura de Zwarte van Haren Cahn Hulshoff Pol Kahn Ayesa-Arriola Ortiz-García de la Foz Tordesillas-Gutierrez Vázquez-Bourgon Crespo-Facorro Alnæs Dahl Westlye Agartz Andreassen Jönsson Kochunov Bruggemann Catts Michie Mowry Quidé Rasser Schall Scott Carr Green Henskens Loughland Pantelis Weickert Weickert de Haan Brosch Pfarr Ringwald Stein Jansen Kircher Nenadić Krämer Gruber Satterthwaite Bustillo Mathalon Preda Calhoun Ford Potkin Chen Tan Wang Xiang Fan Bernardoni Ehrlich Fuentes-Claramonte Garcia-Leon Guerrero-Pedraza Salvador Sarró Pomarol-Clotet Ciullo Piras Vecchio Banaj Spalletta Michielse van Amelsvoort Dickie Voineskos Sim Ciufolini Dazzan Murray Kim Chung Andreou Schmidt Borgwardt McIntosh Whalley Lawrie du Plessis Luckhoff Scheffler Emsley Grotegerd Lencer Dannlowski Edmond Rootes-Murdy Stephen Mayer Antonucci Fazio Pergola Bertolino Díaz-Caneja Janssen Lois Arango Tomyshev Lebedeva Cervenka Sellgren Georgiadis Kirschner Kaiser Hajek Skoch Spaniel Kim Kwak Oh Kwon James Bakker Knöchel Stäblein Oertel Uhlmann Howells Stein Temmingh Diaz-Zuluaga Pineda-Zapata López-Jaramillo Homan Ji Surbeck Homan Fisher Franke Glahn Gur Hashimoto Jahanshad Luders Medland Thompson Turner van Erp Francks
Study Outcome
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Statistics
Citations : American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, ed. 5, 2013).Authors : 149
Identifiers
Doi : e2213880120SSN : 1091-6490