Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Volume: 49
Issue: 3
Year of Publication: 2024
Affiliated Institutions:
Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA.
Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Jiangsu, China.
First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.
Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
University Medical Centre Charité, Berlin, Germany.
Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Department of Psychiatry and Behavioral Science, Texas A&M University, College Station, TX, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Minneapolis VA Health Care System, Minneapolis, MN, USA.
Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Psychology, Vanderbilt University, Nashville, TN, USA.
Veterans Integrated Service Network- Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Department of Comparative Medicine, Yale University, New Haven, CT, USA.
Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. rajendra.morey@duke.edu.
Abstract summary
Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.
Authors & Co-authors:
Yang
Huggins
Sun
Baird
Haswell
Frijling
Olff
van Zuiden
Koch
Nawijn
Veltman
Suarez-Jimenez
Zhu
Neria
Hudson
Mueller
Baker
Lebois
Kaufman
Qi
Lu
Říha
Rektor
Dennis
Ching
Thomopoulos
Salminen
Jahanshad
Thompson
Stein
Koopowitz
Ipser
Seedat
du Plessis
van den Heuvel
Wang
Zhu
Li
Sierk
Manthey
Walter
Daniels
Schmahl
Herzog
Liberzon
King
Angstadt
Davenport
Sponheim
Disner
Straube
Hofmann
Grupe
Nitschke
Davidson
Larson
deRoon-Cassini
Blackford
Olatunji
Gordon
May
Nelson
Abdallah
Levy
Harpaz-Rotem
Krystal
Morey
Sotiras
Study Outcome
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