Associations between abnormal electroencephalogram microstates and childhood emotional abuse in adolescent depression.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Volume: 48

Issue: 11

Year of Publication: 2024

Affiliated Institutions:  Mental Health Center, University-Town Hospital, Chongqing Medical University, Chongqing . jinhuihu@.com. Mental Health Center, University-Town Hospital, Chongqing Medical University, Chongqing . Department of Psychiatry, First Affiliated Hospital, Chongqing Medical University, Chongqing , China. Mental Health Center, University-Town Hospital, Chongqing Medical University, Chongqing . wangwo@cqmu.edu.cn.

Abstract summary 

Childhood traumatic experiences greatly influenced the brain network activities of patients with depression, and there is an urgent need to explore the temporal dynamics for these changes. This study aims to investigate the abnormalities of resting-state electroencephalogram (EEG) microstates in eye-open state of depressed adolescents and to explore the correlations between their EEG microstates and the childhood traumatic experience.Using resting-state EEG microstate analysis, we explored the temporal dynamics of brain activity in patients with adolescent depression. This study selected 66 adolescents with depression as a patient group, and 27 healthy adolescents as a healthy control group. A modified k-means clustering algorithm was used to classify the 64-channel resting-state EEG data into different microstates. Independent sample -tests were used to compare the microstate parameters between the 2 groups and further assciations between these parameters and childhood traumatic experience in patients were explored via using Spearman correlation.In this study, significant differences were observed in the occurrence and transition probabilities of EEG microstates between the healthy control and the patient group. Notably, there was a statistically significant difference (<0.05) in the occurrence of microstate A across 2 groups, exhibiting a negative correlation with the emotional abuse component within the childhood trauma scores (Spearman's rho=-0.31, =0.013). Furthermore, patient-specific, non-random transitions from microstate B to A (Spearman's rho=-0.30, =0.015) and C to A (Spearman's rho=-0.31, =0.013) were inversely associated with the scores of emotional abuse factors from childhood trauma in the patient group, showing statistically significant differences when comparing to the healthy controls (<0.05). Upon stratification into quartiles based on the emotional abuse factor scores, the occurrence of microstate A, as well as the transition rates from microstates B to A and C to A, retained statistical significance following adjustment for multiple comparisons (all <0.05).The abnormal temporal dynamics in brain networks of adolescents with depression are linked to childhood emotional abuse. Those who have suffered severe emotional abuse may show greater impairments in the brain's visual and central executive networks. EEG microstate analysis could be a potential tool for detecting adolescent depression with severe childhood trauma.

Authors & Co-authors:  Hu Zhou Zhao Ma Peng He Chen Chen Jiang Kuang Wang

Study Outcome 

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Statistics
Citations :  Kessler RC. The costs of depression[J]. Psychiatr Clin North Am, 2012, 35(1): 1-14. 10.1016/j.psc.2011.11.005.
Authors :  11
Identifiers
Doi : 10.11817/j.issn.1672-7347.2023.230220
SSN : 1672-7347
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
adolescents;childhood trauma;major depressive disorder;microstate;resting state electroencephalogram
Study Design
Study Approach
Country of Study
Mali
Publication Country
China