Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry.

Journal: Journal of neurology

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Affiliated Institutions:  Department of Neurosciences, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. maurizio.leone@marionegri.it. Department of Neurology, Neurocritical Care Unit, Vienna, Austria. raimund.helbok@kepleruniklinikum.at. Department of Neurosciences, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. University of Campinas, Campinas, Brazil. European Academy of Neurology, Vienna, Austria. Department of Neurology, UHC Sestre Milosrdnice University Hospital Center, Zagreb, Croatia. Department of Neurology, Semmelweis University Budapest, Budapest, Hungary. Tel Aviv University School of Medicine and Shamir (Assaf Harofeh), Medical Center, Tel Aviv, Israel. Neurology Unit ASST Valcamonica-Esine, Brescia, Italy. Neurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS Di Reggio Emilia, Reggio Emilia, Italy. Diomid Gherman Institute of Neurology and Neurosurgery, Chișinău, Moldova. Medical Faculty, University Clinic for Neurology, University "Ss. Cyril and Methodius", Skopje, North Macedonia. Medicine Faculty, Head Neurology Program, Hospital Central "Dr. Ignacio Moronnes Prieto", Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico. Department of Neurology, Oslo University Hospital, Oslo, Norway. Department of Neurology, Specialist Hospital Konskie, Collegium Medicum, Jan Kochanowski University, Kielce, Poland. Department of Neurology, Centro Hospitalar Universitário Do Porto, Porto, Portugal. Neurology Department, Hospital de São João, Porto, Portugal. Neurology Department, Colentina Clinical Hospital, Bucharest, Romania. Centre de Recherche du CHU de Québec, Laval University, Quebec, Canada. Department of Neurology, University Hospital of Bern, Bern, Switzerland. Division of Neurology, Centre Hospitalier Universitaire of Grenoble, Grenoble Alpes University, Grenoble Institute of Neuroscience, Grenoble, France.

Abstract summary 

Several neurological manifestations are part of the post-COVID condition. We aimed to: (1) evaluate the 6-month outcome in the cohort of patients with neurological manifestations during the COVID-19 acute phase and surviving the infection, and find outcome predictors; (2) define the prevalence and type of neurological symptoms persistent at six months after the infection. Data source was an international registry of patients with COVID-19 infection and neurological symptoms, signs or diagnoses established by the European Academy of Neurology. Functional status at six-month follow-up was measured with the modified Rankin scale (mRS), and defined as: "stable/improved" if the mRS at six months was equal as or lower than the baseline score; "worse" if it was higher than the baseline score. By October 30, 2022, 1,003 lab-confirmed COVID-19 patients were followed up for a median of 6.5 months. Compared to their pre-morbid status, 522 patients (52%) were stable/improved, whereas 465 (46%) were worse (functional status missing for 16). Age, hospitalization, several pre-COVID-19 comorbidities, and COVID-19 general complications were predictors of a worse status. Amongst neurological manifestations, stroke carried the highest risk for worse outcome (OR 5.96), followed by hyperactive delirium (2.8), and peripheral neuropathies (2.37). On the other hand, hyposmia/hypogeusia (0.38), headache (0.40), myalgia (0.45), and COVID-19 vaccination (0.52) were predictors of a favourable prognosis. Persisting neurological symptoms or signs were reported by 316/1003 patients (31.5%), the commonest being fatigue (n = 133), and impaired memory or concentration (n = 103). Our study identified significant long-term prognostic predictors in patients with COVID-19 and neurological manifestations.

Authors & Co-authors:  Leone Helbok Bianchi Yasuda Konti Ramankulov Lolich Lovrencic-Huzjan Kovács Armon Cotelli Cavallieri Grosu Kiteva-Trenchevska Rodriguez-Leyva Boldingh Brola Maia de Seabra Davidescu Popescu Kopishinskaia Bassetti Moro

Study Outcome 

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Citations :  Bassetti CLA, Helbok R, Adorjan K, Falkai P (2022) European psychiatric association-european academy of neurology statement on post-COVID syndrome. Eur Psychiatry 65(1):e59. https://doi.org/10.1192/j.eurpsy.2022.2317
Authors :  25
Identifiers
Doi : 10.1007/s00415-024-12212-8
SSN : 1432-1459
Study Population
Male,Female
Mesh Terms
Other Terms
Neurological conditions;Outcome;Post-Covid;Prognosis
Study Design
Study Approach
Country of Study
Publication Country
Germany