Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.
Journal: Schizophrenia bulletin
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Affiliated Institutions: Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad Complutense, Madrid, Spain. Department of Psychiatry, McLean Hospital and Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. Department of Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Software Engineering and Information Technology, École de technologie supérieure, Montréal, Canada. School of Psychology, Institute for Mental Health, University of Birmingham, Birmingham, UK. Department of Psychiatry, University of California, San Diego, CA, USA. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. IBM T.J. Watson Research Center, Yorktown Heights, NY, USA. Department of Psychiatry, University of Hong Kong, Pok Fu Lam, Hong Kong. Department Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA. Olin Neuropsychiatry Research Center, Hartford Hospital, Hartford, CT, USA. Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia. General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA. Centre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health Centre, Glostrup, Copenhagen, Denmark. Department of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. Department of Psychosis Studies, King's College London, London, UK. Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. Department of Psychiatry, IMHAY, University of Chile, Santiago, Chile. Behavioral Health Services, PeaceHealth Medical Group, Eugene, OR, USA. Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen, Denmark. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Department of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. Department of Psychiatry, Washington University Medical School, St. Louis, MO, USA. Northwell Health, Glen Oaks, NY, USA. Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. Department of Psychology, Northwestern University, Evanston, IL, USA. CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Prevention Science Institute, University of Oregon, Eugene, OR, USA. Department of Psychological Science, University of California, Irvine, Irvine, CA, USA. PEPP-Montreal, Douglas Research Centre, Montreal, Quebec, Canada. Department of Psychology, University of Georgia, Athens, GA, USA. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Department of Psychosis, Institute of Mental Health, Singapore. Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. Department of Psychology, Emory University, Atlanta, GA, USA. Institute of Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia. Youth Early Detection/Intervention in Psychosis Platform (Plateforme ERA), Service of Child and Adolescent Psychiatry, Department of Psychiatry, Lausanne University Hospital and The University of Lausanne, Lausanne, Switzerland. Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Department Psychiatry, Beaumont Hospital, Dublin , Ireland. School of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia. Program for Specialized Treatment Early in Psychosis (STEP), CMHC, New Haven, CT, USA. Department of Psychology, Stanford University, Stanford, CA, USA. Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK. Orygen, Parkville, VIC, Australia. Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center,Groningen, Netherlands. Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, Switzerland. Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA. Department of Psychiatry, Neurodevelopment & Psychosis Section, University of Pennsylvania, Philadelphia, PA, USA. Department of Psychology, Yale University, New Haven, CT, USA. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Early Psychosis Detection and Clinical Intervention (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK. Department of Public Mental Health, Central Institute of Mental Health, Heidelberg Univeristy, Mannheim, Germany. School of Psychology, University of Birmingham, Edgbaston, UK. Unidad de imágenes cuantitativas avanzadas, departamento de imágenes, clínica alemana, universidad del Desarrollo, Santiago, Chile.
Abstract summary
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.Authors & Co-authors: Wannan Nelson Addington Allott Anticevic Arango Baker Bearden Billah Bouix Broome Buccilli Cadenhead Calkins Cannon Cecci Chen Cho Choi Clark Coleman Conus Corcoran Cornblatt Diaz-Caneja Dwyer Ebdrup Ellman Fusar-Poli Galindo Gaspar Gerber Glenthøj Glynn Harms Horton Kahn Kambeitz Kambeitz-Ilankovic Kane Kapur Keshavan Kim Koutsouleris Kubicki Kwon Langbein Lewandowski Light Mamah Marcy Mathalon McGorry Mittal Nordentoft Nunez Pasternak Pearlson Perez Perkins Powers Roalf Sabb Schiffman Shah Smesny Spark Stone Strauss Tamayo Torous Upthegrove Vangel Verma Wang Rossum Wolf Wolff Wood Yung Agurto Alvarez-Jimenez Amminger Armando Asgari-Targhi Cahill Carrión Castro Cetin-Karayumak Mallar Chakravarty Cho Cotter D'Alfonso Ennis Fadnavis Fonteneau Gao Gupta Gur Gur Hamilton Hoftman Jacobs Jarcho Ji Kohler Lalousis Lavoie Lepage Liebenthal Mervis Murty Nicholas Ning Penzel Poldrack Polosecki Pratt Rabin Rahimi Eichi Rathi Reichenberg Reinen Rogers Ruiz-Yu Scott Seitz-Holland Srihari Srivastava Thompson Turetsky Walsh Whitford Wigman Yao Yuen Ahmed Byun Chung Do Hendricks Huynh Jeffries Lane Langholm Lin Mantua Santorelli Ruparel Zoupou Adasme Addamo Adery Ali Auther Aversa Baek Bates Bathery Bayer Beedham Bilgrami Birch Bonoldi Borders Borgatti Brown Bruna Carrington Castillo-Passi Chen Cheng Ching Clifford Colton Contreras Corral Damiani Done Estradé Etuka Formica Furlan Geljic Germano Getachew Goncalves Haidar Hartmann Jo John Kerins Kerr Kesselring Kim Kim Kinney Krcmar Kotler Lafanechere Lee Llerena Markiewicz Matnejl Maturana Mavambu Mayol-Troncoso McDonnell McGowan McLaughlin McIlhenny McQueen Mebrahtu Mensi Hui Suen Wong Morrell Omar Partridge Phassouliotis Pichiecchio Politi Porter Provenzani Prunier Raj Ray Rayner Reyes Reynolds Rush Salinas Shetty Snowball Tod Turra-Fariña Valle Veale Whitson Wickham Youn Zamorano Zavaglia Zinberg Woods Shenton
Study Outcome
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Doi : sbae011SSN : 1745-1701