Rebuilding the behavioral inhibition circuit to prevent opioid relapse.

Journal: Neuron

Volume: 112

Issue: 5

Year of Publication: 2024

Affiliated Institutions:  Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing , China. National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing , China; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing , China. National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing , China. Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing , China; National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Research, Peking University, Beijing , China; Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing , China; Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder, Chinese Academy of Medical Sciences, Beijing , China. Electronic address: linlu@bjmu.edu.cn.

Abstract summary 

Failure in behavioral suppression is a key feature in substance use disorders, potentially leading to compulsive drug seeking and relapse. In this issue of Neuron, Paniccia et al. elucidated a heroin-damaged paraventricular nucleus of the thalamus (PVT)-accumbal circuit and how recovery of PVT function could prevent heroin relapse.

Authors & Co-authors:  Liu Lu Han Lu

Study Outcome 

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Statistics
Citations : 
Authors :  4
Identifiers
Doi : 10.1016/j.neuron.2024.01.005
SSN : 1097-4199
Study Population
Male,Female
Mesh Terms
Analgesics, Opioid
Other Terms
Study Design
Study Approach
Country of Study
Publication Country
United States