Abstract summary 

Blood brain barrier disruption (BBBD) can be visualized by contrast extravasation (CE) after endovascular treatment (EVT) in patients with acute ischemic stroke. Elevated blood pressure is a risk factor for BBBD. However, the association between procedural blood pressure and CE post-EVT is unknown.In this single-center retrospective study, we analyzed 501 eligible patients who received a dual energy CT (DECT) immediately post-EVT for acute ischemic stroke. Procedural blood pressure values (SBP, SBP SBP and MAP) were collected. CE was quantified by measuring the maximum parenchymal iodine concentration on DECT iodine overlay map reconstructions. As a measure for the extent of BBBD, we created CE-ASPECTS by deducting one point per hyperdense ASPECTS region on iodine overlay maps. The association between blood pressure and CE was assessed using multivariable linear regression.The procedural SBP, SBP, and MAP were 150±26 mmHg, 173±29 mmHg, and 101±17 mmHg, respectively. The median maximum iodine concentration on post-EVT DECT was 1.2mg/ml (IQR 0.7-2.0), and median CE-ASPECTS was 8 (IQR 5-11). The maximum iodine concentration was not associated with blood pressure. SBP, SBP and MAP were significantly associated with CE-ASPECTS (per 10 mmHg, β = -0.2, 95% CI -0.31 to -0.09, β = -0.15, 95% CI -0.25 to -0.06, β = -0.33, 95% CI -0.49 to -0.17, respectively).In acute ischemic stroke patients undergoing EVT, particularly in ones gaining successful recanalization, SBP, SBP, and MAP are associated with the extent of BBBD on immediate post-EVT DECT, but not with maximum iodine concentration.

Authors & Co-authors:  Robbe Pinckaers Santegoeds Bos van Oostenbrugge van Zwam Staals Postma

Study Outcome 

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