Abstract summary 

Mental disorders (MDs) are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders (CMDs). Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and complete genealogies of Denmark and Sweden (n=17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six MDs and 14 CMDs. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with CMDs, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with CMDs was mainly or fully driven by environmental factors. These findings provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

Authors & Co-authors:  Meijsen Hu Krebs Athanasiadis Washbrook Zetterberg E Silva Shorter Gådin Bergstedt Howard Ye Lu Valdimarsdóttir Ingason Mikkelsen Plana-Ripoll McGrath Micali Andreassen Werge Fang Buil

Study Outcome 

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