Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
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Affiliated Institutions:
Research Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Gait & Brain Lab, St. Joseph' Health Care London, Lawson Health Research, Western University, Division of Geriatric Medicine, London, Ontario, Canada.
Neuroscience, Mobility and Balance Lab, Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Data Science and Advanced Analytics, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.
Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Program, Department of Medicine (Neurology), Sunnybrook Research Institute, Sunnybrook HSC, University of Toronto, Toronto, Ontario, Canada.
Krembil Brain Institute, University Health Network Memory Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Halifax Clinical Psychology Residency Program, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
Division of Neurology, Department of Medicine, Edmond J Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Neuroscience, Mobility and Balance Laboratory, Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, Ontario, Canada.
Abstract summary
Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases.Gait speed, APOE E4, cognition, and neuroimaging were assessed in 480 older adults with neurodegeneration. Participants were grouped by APOE E4 presence and slow gait. Mediation analyses were conducted to determine if brain structures could explain the link between these factors and cognitive performance.APOE E4 carriers with slow gait had the lowest global cognitive performance and smaller gray matter volumes compared to non-APOE E4 carriers with normal gait. Coexistence of APOE E4 and slow gait best predicted global and domain-specific poorer cognitive performances, mediated by smaller gray matter volume.Gait slowness in APOE E4 carriers with neurodegenerative diseases may indicate extensive gray matter changes associated with poor cognition.APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases. Slow gait and smaller gray matter volumes are associated, independently of APOE E4. Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume. Gait slowness in APOE E4 carriers indicates poorer cognition-related brain changes.
Authors & Co-authors:
Sakurai
Pieruccini-Faria
Cornish
Fraser
Binns
Beaton
Dilliott
Kwan
Ramirez
Tan
Scott
Sunderland
Tartaglia
Finger
Zinman
Freedman
McLaughlin
Swartz
Symons
Lang
Bartha
Black
Masellis
Hegele
McIlroy
Montero-Odasso
Study Outcome
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