Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Volume: 

Issue: 

Year of Publication: 

Affiliated Institutions:  Division of Psychiatry, University College London, London, UK. Priment Clinical Trials Unit, University College London, London, UK. David Goldberg Centre (H.), King's College London, London, UK. University of Plymouth, Plymouth, Devon, UK. Birmingham and Solihull NHS Trust, Birmingham, UK. University of East Anglia, Norwich, Norfolk, UK. University of Nottingham Queen's Medical Centre, Nottingham, UK. University of Hull, Hull, UK. Brighton and Sussex School of Medicine, Brighton, East Sussex, UK. Aneurin Bevan NHS Trust, St Cadoc's Hospital, Newport, South Wales, UK. Bradford District Care Foundation Trust, Shipley, UK. University of Newcastle, Campus for Ageing and Vitality, Newcastle upon Tyne, UK. Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. Comprehensive Clinical Trials Unit, University College London, London, UK.

Abstract summary 

Trials of effectiveness of treatment options for depression in dementia are an important priority.Randomized controlled trial to assess adapted Problem Adaptation Therapy (PATH) for depression in mild/moderate dementia caused by Alzheimer's disease.Three hundred thirty-six participants with mild or moderate dementia, >7 on Cornell Scale for Depression in Dementia (CSDD), randomized to adapted PATH or treatment as usual. Mean age 77.0 years, 39.0% males, mean Mini-Mental State Examination 21.6, mean CSDD 12.9. For primary outcome (CSDD at 6 months), no statistically significant benefit with adapted PATH on the CSDD (6 months: -0.58; 95% CI -1.71 to 0.54). The CSDD at 3 months showed a small benefit with adapted PATH (-1.38; 95% CI -2.54 to -0.21) as did the EQ-5D (-4.97; 95% CI -9.46 to -0.48).An eight-session course of adapted PATH plus two booster sessions administered within NHS dementia services was not effective treatment for depression in people with mild and moderate dementia. Future studies should examine the effect of more intensive and longer-term therapy.

Authors & Co-authors:  Howard Cort Rawlinson Wiegand Downey Lawrence Banerjee Bentham Fox Harwood Hunter Livingston Moniz-Cook Panca Raczek Ivenso Russell Thomas Wilkinson Freemantle Gould

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Asmer MS, Kirkham J, Newton H, et al. Meta-analysis of the prevalence of major depressive disorder among adults with dementia. J Clin Psychiatry. 2018;79:17r11772.
Authors :  21
Identifiers
Doi : 10.1002/alz.13766
SSN : 1552-5279
Study Population
Male,Female
Mesh Terms
Other Terms
Alzheimer's disease;clinical trial;depression;mood;problem adaptation therapy;psychological;psychotherapy
Study Design
Study Approach
Country of Study
Publication Country
United States