Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium.
Journal: International journal of cancer
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Affiliated Institutions:
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Division of Prevention, Centre for Public Health Sciences, National Cancer Centre Institute for Cancer Control, Tokyo, Japan.
Sustainable Society Design Center, Graduate School of Frontier Science, The University of Tokyo, Tokyo, Japan.
Division of Cohort Research, National Cancer Centre, Institute for Cancer Control, Tokyo, Japan.
The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.
Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.
Division of Epidemiology, Vanderbilt-Ingram Cancer Centre, Vanderbilt Epidemiology Centre, Vanderbilt University Medical Centre, Nashville, Tennessee, USA.
Department of Public Health, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Radiation Effects Research Foundation, Hiroshima, Japan.
Tohoku University Graduate School of Medicine, Miyagi Prefecture, Japan.
Graduate School of Cancer Science and Policy, National Cancer Centre, Gyeonggi-do, Republic of Korea.
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Centre, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Stony Brook Cancer Centre, Stony Brook University, Stony Brook, New York, USA.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Division of Cancer Epidemiology and Prevention, Aichi Cancer Centre Research Institute, Nagoya, Japan.
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Division of Cancer Epidemiology & Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA.
Abstract summary
The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone-related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16-1.70 for 17 years and older vs. 13-14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50-4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08-2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort.
Authors & Co-authors:
Shin
Cho
Abe
Islam
Rahman
Saito
Kazmi
Katagiri
Merritt
Choi
Shu
Sawada
Tamakoshi
Koh
Sakata
Hozawa
Kim
Park
Kweon
Wen
Tsugane
Kimura
Yuan
Kanemura
Sugawara
Shin
Ahsan
Boffetta
Chia
Matsuo
Qiao
Rothman
Zheng
Inoue
Kang
Study Outcome
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