Associations between immune biomarkers and symptoms of anxiety, depression, and insomnia in paediatric inflammatory bowel disease: A preliminary longitudinal analysis.

Journal: Physiology & behavior

Volume: 278

Issue: 

Year of Publication: 

Affiliated Institutions:  Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy. Electronic address: andrea.ballesio@uniroma.it. Department of Psychology, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy. Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy. Department of Medical-Surgical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Italy.

Abstract summary 

Innate immunity may influence the onset of affective symptoms and alter sleep patterns in chronic inflammatory conditions. Here, we tested the prospective associations between baseline serum C-reactive protein (CRP), albumin, and CRP/albumin ratio (CAR, i.e., an emerging biomarker of disease activity), and self-reported symptoms of anxiety, depression, and insomnia at 1-year follow up in paediatric inflammatory bowel disease (n = 17). After controlling for baseline values, CAR (ρ = 0.591, p = 0.026) predicted anxiety symptoms, while albumin predicted both anxiety (ρ = -0.687, p = 0.007) and insomnia symptoms (ρ = -0.648, p = 0.012). Current findings preliminarily suggest that inflammation may influence anxiety and sleep disturbance in paediatric IBD.

Authors & Co-authors:  Ballesio Santamaria Furio Parisi Polese Micheli Baccini Di Nardo Lombardo

Study Outcome 

Source Link: Visit source

Statistics
Citations : 
Authors :  9
Identifiers
Doi : 10.1016/j.physbeh.2024.114510
SSN : 1873-507X
Study Population
Male,Female
Mesh Terms
Other Terms
Affect;Anxiety;Crohn's disease;Depression;Inflammation;Sleep;Ulcerative colitis
Study Design
Study Approach
Country of Study
Publication Country
United States