Abstract summary 

Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) comorbidity occurs through exposure to trauma with genetic susceptibility. Neuropeptide-Y (NPY) and dopamine are neurotransmitters associated with anxiety and stress-related psychiatry through receptors. We attempted to explore the genetic association between two neurotransmitter receptor systems and the PTSD-MDD comorbidity.Four groups were identified using latent profile analysis (LPA) to examine the patterns of PTSD and MDD comorbidity among survivors exposed to earthquake-related trauma: low symptoms, predominantly depression, predominantly PTSD, and PTSD-MDD comorbidity. (rs4425326), (rs11724320), (rs1079597), and (rs6280) were genotyped from 1,140 Chinese participants exposed to earthquake-related trauma. Main, gene-environment interaction (G × E), and gene-gene interaction (G × G) effects for low symptoms, predominantly depression, and predominantly PTSD were tested using a multinomial logistic model with PTSD-MDD comorbidity as a reference.The results demonstrated that compared to PTSD-MDD comorbidity, epistasis (G × G) - (rs4425326 × rs1079597) affects low symptoms ( = -0.66, = 0.52 [95% CI: 0.32-0.84], = 0.008, = 0.008) and predominantly PTSD ( = -0.56, = 0.57 [95% CI: 0.34-0.97], = 0.037, = 0.039), while - (rs4425326 × rs6280) impacts low symptoms ( = 0.82, = 2.27 [95% CI: 1.26-4.10], = 0.006, = 0.005) and predominantly depression ( = 1.08, = 2.95 [95% CI: 1.55-5.62], = 0.001, = 0.001). The two G × G effects are independent.NPY and dopamine receptor genes are related to the genetic etiology of PTSD-MDD comorbidity, whose specific mechanisms can be studied at multiple levels.

Authors & Co-authors:  Xu Zhang Yang Cao Fang Liu Luo Wang Zhang Wang

Study Outcome 

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