Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study.

Journal: International journal of geriatric psychiatry

Volume: 39

Issue: 3

Year of Publication: 2024

Affiliated Institutions:  Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Division of Neurology, Department of Medicine, Sunnybrook HSC, University of Toronto, Toronto, Ontario, Canada. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada. Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada. McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada. Nova Scotia Health, Halifax, Nova Scotia, Canada. Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada. L.C. Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program Sunnybrook Health Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Robarts Research Institute, Western University, London, Ontario, Canada. Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Bruyère Research Institute, Ottawa, Ontario, Canada. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. St. Joseph's Healthcare Centre, London, Ontario, Canada. Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Thunder Bay Regional Health Research Institute (TBRHRI), Northern Ontario School of Medicine University (NOSMU), Thunder Bay, Ontario, Canada. The Edmond J. Safra Program in Parkinson's Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada. Division of Neurosurgery, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Abstract summary 

Neuropsychiatric symptoms (NPS) increase risk of developing dementia and are linked to various neurodegenerative conditions, including mild cognitive impairment (MCI due to Alzheimer's disease [AD]), cerebrovascular disease (CVD), and Parkinson's disease (PD). We explored the structural neural correlates of NPS cross-sectionally and longitudinally across various neurodegenerative diagnoses.The study included individuals with MCI due to AD, (n = 74), CVD (n = 143), and PD (n = 137) at baseline, and at 2-years follow-up (MCI due to AD, n = 37, CVD n = 103, and PD n = 84). We assessed the severity of NPS using the Neuropsychiatric Inventory Questionnaire. For brain structure we included cortical thickness and subcortical volume of predefined regions of interest associated with corticolimbic and frontal-executive circuits.Cross-sectional analysis revealed significant negative correlations between appetite with both circuits in the MCI and CVD groups, while apathy was associated with these circuits in both the MCI and PD groups. Longitudinally, changes in apathy scores in the MCI group were negatively linked to the changes of the frontal-executive circuit. In the CVD group, changes in agitation and nighttime behavior were negatively associated with the corticolimbic and frontal-executive circuits, respectively. In the PD group, changes in disinhibition and apathy were positively associated with the corticolimbic and frontal-executive circuits, respectively.The observed correlations suggest that underlying pathological changes in the brain may contribute to alterations in neural activity associated with MBI. Notably, the difference between cross-sectional and longitudinal results indicates the necessity of conducting longitudinal studies for reproducible findings and drawing robust inferences.

Authors & Co-authors:  Rashidi-Ranjbar Churchill Black Kumar Tartaglia Freedman Lang Steeves Swartz Saposnik Sahlas McLaughlin Symons Strother Pollock Rajji Ozzoude Tan Arnott Bartha Borrie Masellis Pasternak Frank Seitz Ismail Tang-Wai Casaubon Mandzia Jog Scott Dowlatshahi Hassan Grimes Marras Zamyadi Munoz Ramirez Berezuk Holmes Fischer Schweizer

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Taragano FE, Allegri RF, Lyketsos C. Mild behavioral impairment: a prodromal stage of dementia. Dement Neuropsychol. 2008;2(4):256-260. https://doi.org/10.1590/s1980-57642009dn20400004
Authors :  42
Identifiers
Doi : 10.1002/gps.6074
SSN : 1099-1166
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
MRI;Mild behavioral impairment (MBI);corticolimbic circuit;frontal-executive circuit;neurodegenerative disorders;neuropsychiatric symptoms (NPS)
Study Design
Longitudinal Study,Longitudinal Study,Longitudinal Study,Longitudinal Study,Longitudinal Study,Longitudinal Study
Study Approach
Country of Study
Publication Country
England