Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.

Journal: Research square

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Affiliated Institutions:  Harvard Medical School/McLean Hospital. d Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University. McLean Hospital. Emory University School of Medicine. Blue Halo. McLean Hospital, Harvard Medical School. Washington University School of Medicine. The Alpert Medical School of Brown University, Rhode Island Hospital and The Miriam Hospital. University of North Carolina at Chapel Hill. San Francisco VA Healthcare System; University of California San Francisco. Emory University School of Medicine; Georgia Institute of Technology. Wayne State University School of Medicine. University of North Carolina Chapel Hill. University of Massachusetts Medical School. Vanderbilt University Medical Center. Indiana University School of Medicine. University of Florida College of Medicine -Jacksonville. Cooper Medical School of Rowan University. University of Cincinnati College of Medicine & University of Cincinnati College of Nursing. Beaumont Hospital. Temple University. Perelman School of Medicine at the University of Pennsylvania. University of Pennsylvania. Einstein Medical Center. Jefferson University Hospitals. Wayne State University; Ascension St. John Hospital. Massachusetts General Hospital. Brigham and Women's Hospital. Saint Joseph Mercy Hospital. University of Massachusetts Medical School-Baystate. Department of Emergency Medicine, McGovern Medical School at UTHealth. University of Missouri-St. Louis. Ohio State University College of Dentistry. University of Michigan. Harvard Medical School. Harvard School of Public Health. University of North Carolina. Georgia Institute of Technology, Emory University and Georgia State University.

Abstract summary 

This study examines the association between brain dynamic functional network connectivity (dFNC) and current/future posttraumatic stress (PTS) symptom severity, and the impact of sex on this relationship. By analyzing 275 participants' dFNC data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (r=-0.179, = 0.021) and future (r=-0.166, = 0.029) PTS symptom severity. Also, dynamics of an intra-network brain state correlated with future symptom intensity (r = 0.192, = 0.021). We additionally observed that the association between the network dynamics of the inter-network brain state with symptom severity is more pronounced in females (r=-0.244, = 0.014). Our findings highlight a potential link between brain network dynamics in the aftermath of trauma with current and future PTSD outcomes, with a stronger protective effect of inter-network brain states against symptom severity in females, underscoring the importance of sex differences.

Authors & Co-authors:  Sendi Fu Harnett van Rooij Vergara Pizzagalli Daskalakis House Beaudoin An Neylan Clifford Jovanovic Linnstaedt Germine Bollen Rauch Haran Storrow Lewandowski Musey Hendry Sheikh Jones Punches Swor Gentile Murty Hudak Pascual Seamon Harris Chang Pearson Peak Merchant Domeier Rathlev O'Neil Sergot Sanchez Bruce Sheridan Harte Kessler Koenen McLean Stevens Calhoun Ressler

Study Outcome 

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Citations :  Pitman R. K. et al. Biological studies of post-traumatic stress disorder. Nature Reviews Neuroscience vol. 13 769–787 Preprint at 10.1038/nrn3339 (2012).
Authors :  50
Identifiers
Doi : rs.3.rs-4004473
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Study Population
Females
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Study Design
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Publication Country
United States