Dropout in a clinical trial for comorbid PTSD and MDD among US service members: Are pretreatment characteristics predictive?

Journal: Psychotherapy research : journal of the Society for Psychotherapy Research

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Affiliated Institutions:  Psychological Health and Readiness, Naval Health Research Center, San Diego, CA, USA. Department of Psychiatry, University of California San Diego, San Diego, CA, USA. Directorate of Mental Health, Naval Medical Center San Diego, San Diego, CA, USA.

Abstract summary 

Despite effective treatment options for posttraumatic stress disorder (PTSD), many patients do not complete therapy. This includes U.S. active duty service members, yet factors linked to attendance in this population remain understudied and dropout remains difficult to predict. Additionally, most studies have not examined samples with PTSD and co-occurring major depressive disorder (MDD) despite high rates of comorbidity.The current study explored predictors of dropout among service members with comorbid PTSD and MDD ( = 94) randomized to cognitive processing therapy enhanced with behavioral activation (BA + CPT) or CPT as part of a clinical trial.Using the Fournier approach, only two predictors were associated with lower dropout risk among over 20 examined: shorter duration between pretreatment assessment and Session 1 ( = .041) and past 3-month PTSD treatment engagement ( = .036).Results suggest the possible utility of early momentum in starting therapy and leveraging recent treatment to improve attendance. However, this study also highlights the possible limitations of commonly assessed pretreatment factors in predicting attendance and current challenges in measuring dropout risk. Strategies to improve prediction, such as shifting focus to assess modifiable factors and processes more proximal to dropout during treatment, may be needed. ClinicalTrials.gov identifier: NCT02874131.

Authors & Co-authors:  Kline Otis Norman Hunt Walter

Study Outcome 

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Statistics
Citations : 
Authors :  5
Identifiers
Doi : 10.1080/10503307.2024.2325519
SSN : 1468-4381
Study Population
Male,Female
Mesh Terms
Other Terms
active duty;attendance;behavioral activation;cognitive processing therapy;depression;military
Study Design
Study Approach
Country of Study
Publication Country
England