Development, validation and clinical utility of short-term adverse-effects of electroconvulsive therapy (SAVE) checklist.

Journal: Psychiatry research

Volume: 335

Issue: 

Year of Publication: 

Affiliated Institutions:  Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka India. Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, Karnataka India. Electronic address: vssreeraj@yahoo.com.

Abstract summary 

Electroconvulsive therapy (ECT) is one of the most effective treatments in psychiatry. However, it has many cognitive and non-cognitive adverse effects (AEs). There are lacunae in the literature on systematic assessment of non-cognitive AEs. There is a need for a standard, comprehensive and specific clinical tool to evaluate this. Hence, a checklist of short-term AEs of ECT (SAVE) with a 2-phase assessment was developed. Content validation was done using 15 experts' ratings and predefined content validity ratio and index (CVR and CVI) in a two-stage modified Delphi method. The checklist had a good CVR and CVI with a final tool of 39 items. The tool was sensitive and identified the non-cognitive AEs after ECT. Cardiovascular and musculoskeletal systems displayed the highest incidence. Many participants exhibited delayed recovery in orientation, gait, and stance, highlighting a necessity for meticulous monitoring. SAVE is the first standardised tool to assess short-term ECT-related AEs systematically. This checklist likely identifies clinically significant incidences of adverse effects. Its regular use may enhance the safety of ECT and patient comfort by supporting early identification and intervention for AEs. However, given the transient nature of AEs, further studies are needed to determine their predictive validity for long-term consequences.

Authors & Co-authors:  Uppinkudru Pathak Kumar K S Bagali Pantoji Ezhumalai Parlikar Shah Balachander Sreeraj Mehta Sinha Arumugham Venkatasubramanian Thirthalli

Study Outcome 

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Citations : 
Authors :  16
Identifiers
Doi : 10.1016/j.psychres.2024.115839
SSN : 1872-7123
Study Population
Male,Female
Mesh Terms
Other Terms
Common side effects;Gait;Orientation;Psychiatric disorders;Recovery;Stance
Study Design
Study Approach
Country of Study
Publication Country
Ireland