Childhood adversities characterize the heterogeneity in the brain pattern of individuals during neurodevelopment.
Journal: Psychological medicine
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Affiliated Institutions:
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Integrative Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, PONS Centre, Charité Mental Health, Germany.
Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Psychiatry, Regional Institute of Medical Sciences, Imphal, India.
Division of Mental Health, ICMR-Centre for Ageing and Mental Health, Kolkata, India.
Rishi Valley Rural Health Centre, Madanapalle, Chittoor, India.
Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
Health Equity Cluster, Institute of Public Health, Bangalore, India.
Division of Nutrition, St John's Research Institute, Bengaluru, India.
Department of Psychiatry & Department of Medical Ethics, St John's Research Institute, Bengaluru, India.
SGDP Centre, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
Molecular Genetics Laboratory, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
NeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Center for Public Health, Bristol Medical School, University of Bristol, Bristol, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College, London, UK.
Abstract summary
Several factors shape the neurodevelopmental trajectory. A key area of focus in neurodevelopmental research is to estimate the factors that have maximal influence on the brain and can tip the balance from typical to atypical development.Utilizing a dissimilarity maximization algorithm on the dynamic mode decomposition (DMD) of the resting state functional MRI data, we classified subjects from the cVEDA neurodevelopmental cohort ( = 987, aged 6-23 years) into homogeneously patterned DMD (representing typical development in 809 subjects) and heterogeneously patterned DMD (indicative of atypical development in 178 subjects).Significant DMD differences were primarily identified in the default mode network (DMN) regions across these groups ( < 0.05, Bonferroni corrected). While the groups were comparable in cognitive performance, the atypical group had more frequent exposure to adversities and faced higher abuses ( < 0.05, Bonferroni corrected). Upon evaluating brain-behavior correlations, we found that correlation patterns between adversity and DMN dynamic modes exhibited age-dependent variations for atypical subjects, hinting at differential utilization of the DMN due to chronic adversities.Adversities (particularly abuse) maximally influence the DMN during neurodevelopment and lead to the failure in the development of a coherent DMN system. While DMN's integrity is preserved in typical development, the age-dependent variability in atypically developing individuals is contrasting. The flexibility of DMN might be a compensatory mechanism to protect an individual in an abusive environment. However, such adaptability might deprive the neural system of the faculties of normal functioning and may incur long-term effects on the psyche.
Authors & Co-authors:
Kashyap
Holla
Bhattacharjee
Sharma
Mehta
Vaidya
Bharath
Murthy
Basu
Nanjayya
Singh
Lourembam
Chakrabarti
Kartik
Kalyanram
Kumaran
Krishnaveni
Krishna
Kuriyan
Kurpad
Desrivieres
Purushottam
Barker
Orfanos
Hickman
Heron
Toledano
Schumann
Benegal
Study Outcome
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