Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project.
Journal: International journal of geriatric psychiatry
Volume: 39
Issue: 3
Year of Publication: 2024
Affiliated Institutions:
Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Jewish General Hospital/Lady Davis Hospital, McGill University, Montreal, Québec, Canada.
University of Western Australia, Perth, Western Australia, Australia.
Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey.
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain.
Mental Health Department, Medicine School, Minas Gerais University, Belo Horizonte, Brazil.
GGZ inGeest, Amsterdam UMC, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Amsterdam UMC, VU University, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Division of Geriatric Psychiatry, McLean Hospital, Belmont, Massachusetts, USA.
Laboratory of Neuroscience (LIM-), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Bipolar and Depressive Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII Barcelona, Barcelona, Catalonia, Spain.
Department of Psychiatry, University of California, San Diego, California, USA.
Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Department of Psychiatry, University of Toronto, Center for Addiction & Mental Health, Toronto, Ontario, Canada.
Department of Psychiatry and Behavioral Sciences, McGovern Medical School, UTHealth Houston, Houston, Texas, USA.
Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Lagos Federal Neuropsychiatry Hospital, Lagos, Nigeria.
Department of Clinical Psychology, Leiden University, Leiden, The Netherlands.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain.
Department of Psychiatry, Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada.
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.
Medical Faculty, Bipolar Center Wiener Neustadt, Sigmund Freud University Vienna, Wien, Austria.
Department of Psychiatry, Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Quebec, Canada.
Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, Texas, USA.
Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Psychiatry Service, Hospital de la Ribera, Valencia, Spain.
Abstract summary
The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset.Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601).Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning.In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.
Authors & Co-authors:
Sajatovic
Rej
Almeida
Altinbas
Balanzá-Martínez
Barbosa
Beunders
Blumberg
Briggs
Dols
Forester
Forlenza
Gildengers
Jimenez
Klaus
Lafer
Mulsant
Mwangi
Nunes
Olagunju
Oluwaniyi
Orhan
Patrick
Radua
Rajji
Sarna
Schouws
Simhandl
Sekhon
Soares
Sutherland
Teixeira
Tsai
Vidal-Rubio
Vieta
Yala
Eyler
Study Outcome
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