The Role of Metabolomics and Microbiology in Urinary Tract Infection.

Journal: International journal of molecular sciences

Volume: 25

Issue: 6

Year of Publication: 2024

Affiliated Institutions:  Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun , China.

Abstract summary 

One of the common illnesses that affect women's physical and mental health is urinary tract infection (UTI). The disappointing results of empirical anti-infective treatment and the lengthy time required for urine bacterial culture are two issues. Antibiotic misuse is common, especially in females who experience recurrent UTI (rUTI). This leads to a higher prevalence of antibiotic resistance in the microorganisms that cause the infection. Antibiotic therapy will face major challenges in the future, prompting clinicians to update their practices. New testing techniques are making the potential association between the urogenital microbiota and UTIs increasingly apparent. Monitoring changes in female urinary tract (UT) microbiota, as well as metabolites, may be useful in exploring newer preventive treatments for UTIs. This review focuses on advances in urogenital microbiology and organismal metabolites relevant to the identification and handling of UTIs in an attempt to provide novel methods for the identification and management of infections of the UT. Particular attention is paid to the microbiota and metabolites in the patient's urine in relation to their role in supporting host health.

Authors & Co-authors:  Zheng Wang Yu Zheng An Zhang Zhang Wang Qi Lin Wang

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Tamadonfar K.O., Omattage N.S., Spaulding C.N., Hultgren S.J. Reaching the End of the Line: Urinary Tract Infections. Microbiol. Spectr. 2019;7 doi: 10.1128/microbiolspec.BAI-0014-2019.
Authors :  11
Identifiers
Doi : 3134
SSN : 1422-0067
Study Population
Female,Females
Mesh Terms
Female
Other Terms
inflammation;metabolomics;microbiology;pathogenesis;urinary tract infection
Study Design
Study Approach
Country of Study
Publication Country
Switzerland