Abstract summary 

Altered stimulus generalization has been well-documented in anxiety disorders; however, there is a paucity of research investigating this phenomenon in the context of depression. Depression is characterized by impaired reward processing and heightened attention to negative stimuli. It is hypothesized that individuals with depression exhibit reduced generalization of reward stimuli and enhanced generalization of loss stimuli. Nevertheless, no study has examined this process and its underlying neural mechanisms. In the present study, we recruited 25 participants with subthreshold depression (SD group) and 24 age-matched healthy controls (HC group). Participants completed an acquisition task, in which they learned to associate three distinct pure tones (conditioned stimuli, CSs) with a reward, a loss, or no outcome. Subsequently, a generalization session was conducted, during which similar tones (generalization stimuli, GSs) were presented, and participants were required to classify them as a reward tone, a loss tone, or neither. The results revealed that the SD group exhibited reduced generalization errors in the early phase of generalization, suggesting a diminished ability to generalize reward-related stimuli. The event-related potential (ERP) results indicated that the SD group exhibited decreased generalization of positive valence to reward-related GSs and heightened generalization of negative valence to loss-related GSs, as reflected by the N1 and P2 components. However, the late positive potential (LPP) was not modulated by depression in reward generalization or loss generalization. These findings suggested that individuals with subthreshold depression may have a blunted or reduced ability to generalize reward stimuli, shedding light on potential treatment strategies targeting this particular process.

Authors & Co-authors:  Qiu Dou Wang Zhang Zhang Shen Li Lei

Study Outcome 

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