Long-term neurocognitive and educational outcomes of neonatal insults in Kilifi, Kenya.

Journal: BMC psychiatry

Volume: 20

Issue: 1

Year of Publication: 2021

Affiliated Institutions:  Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, P.O Box , Kilifi, Kenya. dmagai@kemri-wellcome.org. Department of Clinical, Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Van der Boechorststraat , BT, Amsterdam, The Netherlands. Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, P.O Box , Kilifi, Kenya.

Abstract summary 

There is little data on the long-term neurocognitive and educational outcomes among school-aged survivors of neonatal jaundice (NNJ) and hypoxic-ischemic encephalopathy (HIE) in Africa. This study investigates the long-term neurocognitive and educational outcomes and the correlates of these outcomes in school-aged survivors of NNJ or HIE in Kilifi, Kenya.We conducted a cross-sectional study on neurocognitive and educational outcomes among school-aged survivors (6-12 years) of NNJ (n = 134) and HIE (n = 107) and compared them to a community comparison group (n = 134). We assessed nonverbal intelligence, planning, working memory, attention, syntax, pragmatics, word-finding, memory, perceptual-motor, mathematical, and reading abilities. We also collected information on medical history, caregivers' mental health, and family environment.The survivors of NNJ had lower mean total scores in word-finding [F (1, 250) = 3.89, p = 0.050] and memory [F (1, 248) = 6.74, p = 0.010] than the comparison group. The survivors of HIE had lower mean scores in pragmatics [F (1, 230) = 6.61, p = 0.011] and higher scores higher scores in non-verbal reasoning [F (1, 225) =4.10, p = 0.044] than the comparison group. Stunted growth was associated with almost all the outcomes in HIE.Survivors of NNJ and HIE present with impairment in the multiple domains, which need to be taken into consideration in the planning of educational and rehabilitative services.

Authors & Co-authors:  Magai Koot Mwangi Chongwo Newton Abubakar

Study Outcome 

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Citations :  English M, Ngama M, Musumba C, Wamola B, Bwika J, Mohammed S, et al. Causes and outcome of young infant admissions to a Kenyan district hospital. Arch Dis Child. 2003;88(5):438–443. doi: 10.1136/adc.88.5.438.
Authors :  6
Identifiers
Doi : 578
SSN : 1471-244X
Study Population
Male,Female
Mesh Terms
Aged
Other Terms
Children;Disability;Hypoxic-ischemic encephalopathy;Neonatal jaundice;Neurocognitive impairment
Study Design
Study Approach
Country of Study
Kenya
Publication Country
England