Long COVID, a comprehensive systematic scoping review.

Journal: Infection

Volume: 49

Issue: 6

Year of Publication: 2021

Affiliated Institutions:  Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, PA, , USA. Department of Psychiatry, University of Nairobi, Nairobi, Kenya. Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Cardiology Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, , USA. Pulmonary and Critical Care Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA. Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Professor of Medicine-Nephrology, Saint Louis University School of Medicine, Saint Louis, MO, USA. bahar.bastani@health.slu.edu.

Abstract summary 

To find out what is known from literature about Long COVID until January 30, 2021.We undertook a four-step search with no language restriction. A preliminary search was made to identify the keywords. A search strategy of all electronic databases resulted in 66 eligible studies. A forward and backward search of the references and citations resulted in additional 54 publications. Non-English language articles were translated using Google Translate. We conducted our scoping review based on the PRISMA-ScR Checklist.Of 120 papers, we found only one randomized clinical trial. Of the 67 original studies, 22 were cohort, and 28 were cross-sectional studies. Of the total 120 publications, 49.1% focused on signs and symptoms, 23.3% on management, and 10.8% on pathophysiology. Ten publications focused on imaging studies. The results are also presented extensively in a narrative synthesis in separated sections (nomenclature, diagnosis, pathophysiology, risk factors, signs/symptoms, management).The controversies in its definition have impaired proper recognition and management. The predominant symptoms were: fatigue, breathlessness, arthralgia, sleep difficulties, and chest pain. Recent reports also point to the risk of long-term sequela with cutaneous, respiratory, cardiovascular, musculoskeletal, mental health, neurologic, and renal involvement in those who survive the acute phase of the illness.

Authors & Co-authors:  Akbarialiabad Taghrir Abdollahi Ghahramani Kumar Paydar Razani Mwangi Asadi-Pooya Malekmakan Bastani

Study Outcome 

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Statistics
Citations :  Honigsbaum M, Krishnan L. Taking pandemic sequelae seriously: from the Russian influenza to COVID-19 long-haulers. Lancet. 2020;396:1389–1391. doi: 10.1016/S0140-6736(20)32134-6.
Authors :  11
Identifiers
Doi : 10.1007/s15010-021-01666-x
SSN : 1439-0973
Study Population
Male,Female
Mesh Terms
COVID-19
Other Terms
COVID-19;Corona virus;Long COVID-19;Long haulers COVID;Novel Corona Virus 2019;PASC post-acute sequela SARS-COV-2;Post COVID-19 Syndrome;Post-acute COVID-19;Post-acute SARS-CoV-2;SARS-Cov-2
Study Design
Study Approach
Country of Study
Kenya
Publication Country
Germany