The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America.

Journal: BMJ open

Volume: 14

Issue: 1

Year of Publication: 2024

Affiliated Institutions:  Université de Bordeaux, Bordeaux, France. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. Centre Hospitalier Universitaire Sourô Sanou, Bobo Dioulasso, Burkina Faso. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Indiana University Center for Global Health Equity, Indianapolis, Indiana, USA. TREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand. Vanderbilt Tuberculosis Center, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of the Congo. Mbarara University of Science and Technology Faculty of Medicine, Mbarara, Uganda. The Kirby Institute, UNSW, Sydney, New South Wales, Australia. The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. Department of Medicine, Moi University College of Health Sciences, Eldoret, Kenya. Health Economics and Epidemiology Research Office, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Vanderbilt Institute of Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Centre de Prise en Charge de Recherche et de Formation (Aconda-CePReF), Abidjan, Côte d'Ivoire. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA. Center for Infectious Disease Research in Zambia (CIDRZ), Lusaka, Zambia. Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. The Ryan White Center for Pediatric Infectious Diseases and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA lenane@iu.edu.

Abstract summary 

Tuberculosis (TB) is a leading infectious cause of death globally. It is the most common opportunistic infection in people living with HIV, and the most common cause of their morbidity and mortality. Following TB treatment, surviving individuals may be at risk for post-TB lung disease. The TB Sentinel Research Network (TB-SRN) provides a platform for coordinated observational TB research within the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.This prospective, observational cohort study will assess treatment and post-treatment outcomes of pulmonary TB (microbiologically confirmed or clinically diagnosed) among 2600 people aged ≥15 years, with and without HIV coinfection, consecutively enrolled at 16 sites in 11 countries, across 6 of IeDEA's global regions. Data regarding clinical and sociodemographic factors, mental health, health-related quality of life, pulmonary function, and laboratory and radiographic findings will be collected using standardised questionnaires and data collection tools, beginning from the initiation of TB treatment and through 12 months after the end of treatment. Data will be aggregated for proposed analyses.Ethics approval was obtained at all implementing study sites, including the Vanderbilt University Medical Center Human Research Protections Programme. Participants will provide informed consent; for minors, this includes both adolescent assent and the consent of their parent or primary caregiver. Protections for vulnerable groups are included, in alignment with local standards and considerations at sites. Procedures for requesting use and analysis of TB-SRN data are publicly available. Findings from TB-SRN analyses will be shared with national TB programmes to inform TB programming and policy, and disseminated at regional and global conferences and other venues.

Authors & Co-authors:  Marcy Huebner Yotebieng Poda Fenner Wools-Kaloustian Sohn Sterling de Castro Tabala Byakwaga Rupasinghe Ballif Pierre Freeman Akpata Zotova Diero Evans Ross Figueiredo McDade Mbonze Messou Navuluri Bolton-Moore Duda Chanyachukul Enane

Study Outcome 

Source Link: Visit source

Statistics
Citations :  World Health Organization . Global tuberculosis report 2022. Geneva, 2022.
Authors :  30
Identifiers
Doi : e079138
SSN : 2044-6055
Study Population
Male,Female
Mesh Terms
Adolescent
Other Terms
HIV & AIDS;Observational Study;Tuberculosis
Study Design
Cohort Study
Study Approach
Country of Study
Kenya
Publication Country
England