Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences.
Journal: General hospital psychiatry
Volume: 90
Issue:
Year of Publication:
Affiliated Institutions:
Biggs Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Faculdade Santa Casa BH, Belo Horizonte, Brazil. Electronic address: teixeiraa@uthscsa.edu.
Medical School, University of Western Australia, Perth, Australia.
Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Canada.
Department of Psychiatry, Medical School, Minas Gerais University, Belo Horizonte, Brazil.
Department of Psychiatry, Dalhousie University, Hallifax, Nova Scotia, Canada.
Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey.
Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain.
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Departments of Psychiatry and Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.
Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Amsterdam UMC, VU University, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA.
Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA.
Laboratory of Neuroscience (LIM-), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
University of Groningen, Groningen, the Netherlands.
Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitario de Alava, BIOARABA, UPV/EHU, Vitoria, Spain; CIBERSAM, ISCIII, Spain.
Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain.
Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.
Federal Neuropsychiatric Hospital, Lagos, Nigeria.
GGZ in Geest Mental Health Care, Amsterdam, The Netherlands; Amsterdam UMC, VU University, Department of Psychiatry, Boelelaan , Amsterdam, The Netherlands; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, The Netherlands.
Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA.
IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain.
GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.
Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, TX, USA.
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Abstract summary
To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.
Authors & Co-authors:
Teixeira Antonio L AL
Almeida Osvaldo P OP
Lavin Paola P
Barbosa Izabela G IG
Alda Martin M
Altinbas Kursat K
Balanzá-Martínez Vicent V
Briggs Farren B S FBS
Calkin Cynthia C
Chen Peijun P
Dols Annemieke A
Eyler Lisa T LT
Forester Brent P BP
Forlenza Orestes V OV
Gildengers Ariel G AG
Hajek Tomas T
Haarman Benno B
Korten Nicole N
Jimenez Esther E
Lafer Beny B
Levin Jennifer B JB
Montejo Laura L
Nunes Paula V PV
Olagunju Andrew T AT
Oluwaniyi Stephen S
Oudega Mardien L ML
Patrick Regan E RE
Radua Joaquim J
Rej Soham S
Schouws Sigfried S
Soares Jair C JC
Sutherland Ashley N AN
Vieta Eduard E
Yala Joy J
Sajatovic Martha M
Study Outcome
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