Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS).
Journal: CNS spectrums
Volume: 23
Issue: 1
Year of Publication: 2019
Affiliated Institutions:
Department of Psychiatry,University of Milan,Fondazione IRCCS Ca'Granda,Ospedale Maggiore Policlinico,Milano,Italy.
Department of Psychiatry and Behavioral Sciences,Albert Einstein College of Medicine and Montefiore Medical Center,New York,New York,USA.
Mental Health Unit,Hertfordshire Partnership Foundation Trust,Queen Elizabeth II Hospital,Welwyn Garden City,United Kingdom.
MRC Unit on Anxiety and Stress Disorders,Department of Psychiatry and Mental Health,University of Cape Town,Cape Town,South Africa.
Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN),Mexico City,Mexico.
Carracci Medical Group,Mexico City,Mexico.
Dipartimento di Psichiatria,Neurobiologia,Farmacologia e Biotechnologie,Università di Pisa,Italy.
Department of Psychiatry,University of Florence,and Institute of Neurosciences,Florence,Italy.
Department of Psychiatry and Behavioural Neurosciences,McMaster University,Hamilton,Ontario,Canada.
MRC Unit on Anxiety and Stress Disorders,Department of Psychiatry,University of Stellenbosch,South Africa.
Department of Psychiatry,Sisli Eftal Teaching and Research Hospital,Istanbul,Turkey.
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum,Sofia,Bulgaria.
Department of Psychiatry,Academic Medical Center,University of Amsterdam,Amsterdam,The Netherlands.
National and Trustwide Services for OCD/BDD,SW London and St. George's,National Health Service Trust,London,United Kingdom.
Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,California,USA.
Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Illinois,USA.
Psychiatry Unit at the Hospital Universitari de Bellvitge-IDIBELL,University of Barcelona, Cibersam,Barcelona,Spain.
Tel Aviv University, Sackler School of Medicine, Israel Post-Trauma Center, Research Foundation by the Sheba Medical Center,Israel.
Abstract summary
Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCD patients.A total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson's chi-squared and t tests. Logistic regression was performed to assess the impact of the collected data on the SA variable.14.6% of our sample reported at least one SA during their lifetime. Patients with an SA had significantly higher rates of comorbid psychiatric disorders (60 vs. 17%, p<0.001; particularly tic disorder), medical disorders (51 vs. 15%, p<0.001), and previous hospitalizations (62 vs. 11%, p<0.001) than patients with no history of SA. With respect to geographical differences, European and South African patients showed significantly higher rates of SA history (40 and 39%, respectively) compared to North American and Middle-Eastern individuals (13 and 8%, respectively) (χ2=11.4, p<0.001). The logistic regression did not show any statistically significant predictor of SA among selected independent variables.Our international study found a history of SA prevalence of ~15% in OCD patients, with higher rates of psychiatric and medical comorbidities and previous hospitalizations in patients with a previous SA. Along with potential geographical influences, the presence of the abovementioned features should recommend additional caution in the assessment of suicide risk in OCD patients.
Authors & Co-authors:
Dell'Osso Bernardo B
Benatti Beatrice B
Arici Chiara C
Palazzo Carlotta C
Altamura A Carlo AC
Hollander Eric E
Fineberg Naomi N
Stein Dan J DJ
Nicolini Humberto H
Lanzagorta Nuria N
Marazziti Donatella D
Pallanti Stefano S
van Ameringen Michael M
Lochner Christine C
Karamustafalioglu Oguz O
Hranov Luchezar L
Figee Martijn M
Drummond Lynne L
Rodriguez Carolyn I CI
Grant John J
Denys Damiaan D
Menchon Jose M JM
Zohar Joseph J
Study Outcome
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